Zombie Cells (David Sinclair Book LIFESPAN - Part 8)

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ABOUT THIS VIDEO: This video is part 8 of our series on David Sinclair's new book, "Lifespan: Why We Age and Why We Don't Have To." Here, we talk about "zombie cells" or senescent cells. These cells shut off epigenetics and many other cellular functions. They might help with cancer and healing, but they can aggravate inflammation and aging. Mayo developed Sprycel, a combination of dasatinib and quercetin, to deal with zombie cells. When applied to lab animals, Sprycel led to a 30% improvement in lifespan.
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ABOUT DR. BREWER:
Dr. Brewer started as an Emergency Doctor. After seeing too many preventable heart attacks, he went to Johns Hopkins to learn Preventive Medicine. While there, he went on the run the post-graduate training program (residency) in Preventive Medicine. From there, he made a career of practicing and managing preventive medicine and primary care clinics. His later role in this area was Chief Medical Officer for Premise, which has close to 1,000 primary care/prevention clinics. He was also the Chief Medical Officer for MDLIVE, the second largest telemedicine company. More recently, he founded PrevMed, a heart attack & stroke prevention clinic.

At PrevMed, we focus on heart attack, stroke, and cognitive decline. We serve patients who have already experienced an event as well as those who have not developed a diagnosis or event. Dr. Brewer provides services via telemedicine or in-person if you're in the Lexington, KY area. We find a lot of undiagnosed prediabetes or insulin resistance. Treating unrecognized risk factors like prediabetes allows the reduction of risk and prevention of disease.

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[jlvandat]

Excellent commentary regarding Dr. Sinclairs new book. Your summary helps tremendously to explain and expand upon very important new findings. It's much appreciated. There's so much new information in this field (and most every other science and technology) that I believe that the "palatable distribution" is a service that's both crucial and increasingly valuable.

[untouchable]

Sinclair is dynamic. thanks Dr Brewer!

[bennguyen]

Would like to hear David Sinclair's take on fellow NAD coenzyme researcher Charles Brenner, who is a bit critical of supplementing with NAD precursors (NAM/NMN/NA) except for NR (Tru Niagen). Charles also mentions that pterostilbene is a more bio-available form of resveratrol, yet that appears to raise LDL in humans, so he is skeptical about these compounds.


I'd also love to hear a discussion between evolutionary biologist Michael Rose and David.. Michael suggests it's hundreds of genes that become maladaptive as you age.. and doesn't believe the techniques to manipulate some pathway (ex. AMPK/MTOR/NAD via CR mimetics) will work on humans. Incidentally, Steven Austad, Keith Baar and Aubrey de Grey have also expressed reasons why Caloric-Restriction does not have much lifespan effect in humans.

BTW, looking forward to David's friendly bet with Geoffrey Woo, that suggests changing gene expression of unhealthy cells, causes it mimic adjacent healthy cells.. while David I believe says that each cell has an original dna 'observer' copy that just needs to be activated.

[ann]

Thank you for this video. Very informative.

[abc_cba]

Red Onion has high content of absorbable Quercetin . Oral supplements are not bioavailable and less than 20% of that consumed is made to the liver.

Rutin compound obtained from Apple is a stable version of Quercetin. A little research would help. Thanks.