TWiV 1034: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate,
association between nose picking and SARS-CoV-2 incidence, a cohort study in hospital health care workers; effect of COVID-19 vaccination and booster on maternal-fetal outcomes, dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA, does monoclonal antibody treatment for COVID-19 impact short and long- term outcomes in a large generalizable population, persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation, core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts.

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Twitter: @profvrr

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– Who Am I? –

I’m Vincent Racaniello, Earth’s Virology Professor.

I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

New videos are uploaded several times each week.

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#microbe #viruses #coronavirus #pandemic
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[lesfaby]

YouTube timestamps by Les
00:33 Covid case numbers
01:25 Quotation
02:17 RSV
MAB Beyfortus for infants passive vaccination
04:27 Flu
Trial OVX836 Universal nucleoprotein vaccine
07:18 CoViD
07:30 variant EG.5
variant FL.1.5.1
08:05 chart showing dominant strains
08:23 Post exposure testing
12:28 effect of COVID-19 vaccination and booster on maternal-fetal outcomes
15:30 dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA
19:00 does monoclonal antibody treatment for COVID-19 impact short and long- term outcomes in a large generalizable population
22:37 Long CoViD
22:38 persistent endothelial dysfunction in post-COVID-19 syndrome and
its associations with symptom severity and chronic inflammation
25:49 core mitochondrial genes are down-regulated during
SARS-CoV-2 infection of rodent and human hosts
30:16 Please contribute
30:40 Questions answered
30:44 Mary
32:51 Catherine
34:15 Louise
35:05 Carolyn
36:16 Diana
Audio podcast timestamps by Jolene

[Susanonwow]

30 years ago, my 4 month old almost died to RSV. We were lucky. I’m so glad that there are new tools that can prevent this nightmare for others.

[WillNewcomb]

It's Saturday. It's Vincent & Daniel time✅✅✅

[janakingking]

Thank you for continuing to keep us informed!

[karenkaren]

Got my Covid booster last week since cases are rising and I volunteer in a hospital.
In the Fall will get my flu and RSV shots.

Retired Nurse

[rosalindmartin]

An interesting listen always (barely understanding med terms) .. i am 80yoa .. few body problems other than dental... so I check for possible booster and other safety recommendations.
(Rarely pick nose)

[Graham_Wideman]

Drs Racaniello and Griffin: 1. Attempting to post a comment on the show-notes page results in a reCAPTCHA verification fail, with seemingly no way to actually perform a reCAPTCHA test. 2. I'd appreciate a link to the "weighted estimates in HHS Region 2" doc with the graph shown at about 8:00 in the video. Dr Griffin mentions leaving a link, but it doesn't seem to be there on the show notes page. Thanks.

[LisaMartinez-rive]

There is a definite Covid uptick in Columbus, Oh. and there is an awareness to ask the Dr. about Paxlovid. Frankly you do not need to ask because it is the plan of care document.Everyone I know seems to be aware of the criteria for Paxlovid. People I know feel so much better 24 hours later after taking it. Drs are not resistant to prescribe it
If the patient meets the criteria.

[johnvtram]

I have gotten a heavy dose of respiratory infections this year probably due to inhaling infectious microbes during school meetings. We need to keep sick people away from public places because these waves of diseases are out pacing vaccines.

[SamShinnick]

Have they said anything about people with long covid and how they are handling the vaccines? Anecdotally I've heard of long haulers getting better but also some getting worse from taking a booster after already having long covid

[katiehettinger]

Those who do not study history are doomed to repeat it. The concept definitely applies to pandemics. 😏💙🇺🇸🕊

[dannymurzea]

our covid hospitalizations are not for resp failure. its not the same hospitalization. still havent seen a diffuse viral pna since delta

[Nojoyhere]

What's your opinion on this vaccine Rolling out in September?

[everyoung]

We are having an uptick in Covid hospitalizations here in north central Texas. I am sorry to see many outpatient doctors and midlevels are still prescribing steroids and Azithromycin. I’m also seeing Doxycycline and my own (former) PCP is still prescribing hydroxychloroquine. 🤦🏻‍♀️

[johnvtram]

I need the scientists to help address whether diet and vitamins help boost your immune system because i usually get sick when i rush to eat and drink pop

[BigFred]

Actually, some people still mask. I mask when I go out. I have a slight immunocompromised condition ( decreased IGG-G production). Also, I live in the very center of mask denial- the Southeast, but when ever I go out I see people wearing masks still. Not many, my wife doesn't mask for example - however about 3 or 4% of the people are still wearing masks and I find that percentage is highly comprised of African American males over 40. It is interesting because masking became a badge of being a 'weak minded liberal Democrat' whereas strong "conservatives' did not mask (what nonsense over a non-partisan public health issue). I plan on continuing to mask, because it isn't over till the Fat-Covid virus sings and I have not heard that sweet deep song yet.

[sergioduran]

Hi Doctor, congrats for your channel. I’m a nurse, and I find quit interesting in the minute 14:31 the findings about vaccinated pregnant women data, but don’t mention those women to had contracted Covid, so at this point I wonder how it is possible that less miscarriage, heavier and at term babies are born within vaccinated women and what is the relationship with the vaccination status. It don’t make any sense.

[dnorris]

I was told Friday morning I had come into contact with a person who tested positive to Covid. I was around this person Thursday afternoon. What is the protocol today - do I isolate and for how long? And yes, I unfortunately pick my nose. I know it's wrong. I have allergies and my nose drips a lot.

[spamletspamley]

I've read that the 'Hitler' moustache was adopted due to troops having to wear gas masks in WWI in which he was exposed to gas attacks.

[nancychandler]

We see how overuse of antibiotics ties in with the need for mRNA vaccines. Overuse of antibiotics can decrease ribosome count.