IgA Nephropathy Uncovered: Symptoms, Diagnosis & Latest Treatments

Are you interested in a life that's not just longer but also healthier? Dr. Sean Hashmi delves into kidney health, nutrition, weight loss, and the science of longevity in our weekly "Live Long & Thrive" webinar. Each episode is packed with actionable, evidence-based advice, so mark your calendar, prepare your questions, and subscribe today!

Timestamps
00:00 Start
1:26 What is IgA nephropathy
7:56 Other diseases linked to IgA
8:40 Prevention of IgA nephropathy
10:02 Symptoms
15:11 Diagnosis
17:57 Treatment

References:
-World Health Organization . Guideline: Sodium Intake for Adults and Children. World Health Organization; Geneva, Switzerland: 2012. pp. 1–46.
-Wright JA, Cavanaugh KL. Dietary sodium in chronic kidney disease: a comprehensive approach. Semin Dial. 2010 Jul-Aug;23(4):415-21.
-Verma A, Popa C. The Interplay Between Dietary Sodium Intake and Proteinuria in CKD. Kidney Int Rep (2023) 8, 1133–1136
-Reich, H et al. Remission of proteinuria improves prognosis in IgA nephropathy. J Am Soc Nephrol. 2007;18(12):3177.

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#kidneyhealth #longevity #nutrition

[SELFPrinciple]

Thanks for joining the livestream. If you missed it, we have these live streams weekly on Fridays from 5pm-530pm PST. This video covers everything you need to know about IgA nephropathy from diagnosis to treatment. See you next week!. 2 meds that I didn't have time to cover. First was target-release budesonide (Tarpeyo). This is an oral targeted release formulation of budesonide that releases in the distal ileum of the small interesting where its thought that IgA1 production is occurring. It has 90% first-pass liver clearance so has much less systemic sffect than oral steroids. This is the key selling point for tarpeyo. The second drug is sibeprenlimab. A Proliferation-Inducing Ligand (APRIL) is shown in the pathogensis of IgA nephropathy. When we look at patients with IgA, we see that APRIL levels are higher in their blood. A phase II study showed that sibeprenlimab had up to a 62% reduction in 24 hour proteinuria at 12 months (vs 20% with placebo). The best part was the adverse events were similar between the two groups.

[jesperchristensen]

Thank you for this presentation on IGA nephropathy! I love how you explain things. You seem so genuine and keen to help and educate ❤

[asformeandmyhousewewillser]

Listening Tonight from San Diego County. ☔ We Love & Appreciate You, Dr. Hashmi. ❤️ Thank You, So Much for Everything That You Do.

[DIABETESHEALTHS]

Thanks. I am listening from Australia.i have been a long time listener.

[barbarawienand]

You are a breath of fresh air. Thank you.

[Braisin-Raisin]

I was diagnosed through a kidney biopsy to have MCD. I had never been sick before, I am slim and eat mostly vegetarian but not all. No idea why this happenbed. Was put on a course of Prednisone, starting with 60 mg. The kidneys are still, thank goodness, in the normal range. I noticed before that I have less foaming in the urine when I eat plant-based protein. I told this to my nephrologist but he was not impressed. I now take Ramipril for blood pressure and Jardiance. The blood pressure has gone down considerably but want it to reduce even more. I saw, accidentally, your video on plant-based diet which made logical sense to me. I now fill an egg cup with 4 g salt and I salt no food. I add it from my reserve of 4 grams. I have salt in my home-baked bread. Am keeping a diary and it is too early to tell, but the foaming reduced drastically with almost no salt and plant based protein even after 1 day! I also took Atorvastatin but I discontinued this to find out, if it causes the extreme hair loss. The problem is that many conventional doctors only treat with tablets and one needs to make ones own research, and not fall for sensationalism. I am from Northern Germany and am 80.

[stellabella]

So glad I found you. I am 88 and have been on a Plant Based, calorie restriction diet for 3 years now. I have good health and a good mind, do my own shopping, cooking and have a great scooter to get around. My knees are my biggest problem and an irregular heart beat. I have a good Doctor and have heart beat under control. I have been listening to many of your tube videos on your advice and information. Thanks, Blessings to you, your daughters and wife.

[TheFlutism]

Thank you so much for this video. It really helped me understand my disease better.

[thomaslevine]

Listening from SE Asia and a regular listener.

[brizraneesumboo]

Listening from mauritius very clear and concise explanation.Thank you Doctor.

[coleford]

My neph. Has me on 100 mg of Losartan and 20 mg of Lisinopril. He was very hesitant to give the okay on Jardiance after his fill in Dr. Prescribed Farxiga, but insurance doesn't cover that anymore. His interim Dr. did not want me to take both ARB and Ace inhibitors. I have cut my losartan in half on my own, and my GFR has improved. My creatinine levels are slowly improving. What are your thoughts

[Theafire]

Excellent info. Best nephro on youtube. Are there any good books on this subject that you recommend?

[romarcarl]

My friend has IgG4 kidney disease. What's the difference between IgA and IgG4?

[ilmendo]

Doc I have been diagnosed with seronegative celiac disease 7 years ago.
I also had gastroparesis, EoE and colitis.
Now after 7 years I have high hemoglobulin and on my urine test I have a really high lymphocytes count.
Are there any correlation between immature cd19 and kidney failure ?
Thanks

[jesperchristensen]

I'm spilling about 300mg/day protein and it has been stable since i was diagnosed by biopsy 3 years ago. My doc has put me on candarsartan 4mg. My natural blood pressure is around 120/80 and not much lower on candarsartan. There doesn't seem to be any difference in my proteinuria with or without condarsartan. Is it still adviced for me to continue the medication?

[simonsteadman]

Wonderful informative video Sean, can you discuss Tarpeyo (Budesonide) and other new drugs as well as those mentioned here.
Thank you❤👏

[Mayankumar-mfwp]

Hi we are from India
I am a patient of iga nephropathy
S creatinine 1.8
Urine protein 1.8g 24 hours
Currently taken medicine
Telma-40
Atorva
Nexiiron
Please suggest best treatment

[Tobias-utxi]

Hi Sean, thanks for the video. Could you make a particular video covering Tarpeyo? It would be great with a video solely covering it's use given it's the first FDA approved medicine that has a proven disease modifying effect on IgA Nephropathy. Thanks again

[kolasola]

Hello, thx for the video!
Am I understood correctly if f.e. I got less protein than 0.5 g per day only on losartan does that mean that I don't have to add more medications and stay on losartan further?

[AletaScott-vv]

I was diagnosed with Bell's Palsy and Ear infection at the end of the year. How will this affect my Kidneys. I'm also Bipolar.
Any suggestions