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Pathway of Pain and Temperature Sensation, Dr Adel Bondok
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Dr Adel Bondok Neuroanatomy Teaching Videos.
You should know:
1. The receptors.
2. The pain fibers (A-delta and C-fibers).
3. The tract: lateral spinothalamic tract.
4. The 1st, 2nd and 3rd order neuron.
5. Effect of a lesion in the lateral spinothalamic tract.
Function of the Substantia Gelatinosa (lamina II):
Substantia gelatinosa consists of small neurons (Golgi type II) which have short axons. The short axons synapse with neurons of the nucleus proprius and the posteromarginal nucleus to inhibit pain transmission.
It does not contain large cells. Therefore, it does not form the lateral spinothalamic tract.
Inhibition of Pain Sensation:
1. Substantia gelatinosa cells release enkephalins which inhibit the release of substance P from the pain fibers (A-delta and C-fibers) of DRG.
2. SG cells receive excitatory impulses from the following sources for pain suppression:
a. Sensory area of the cerebral cortex via the corticospinal tract (NE).
b. Touch fibers from gracile and cuneate tracts (glutamate).
c. Raphe magnus nucleus (reticular formation) via the raphe-spinal tract (serotonin).
You should know:
1. The receptors.
2. The pain fibers (A-delta and C-fibers).
3. The tract: lateral spinothalamic tract.
4. The 1st, 2nd and 3rd order neuron.
5. Effect of a lesion in the lateral spinothalamic tract.
Function of the Substantia Gelatinosa (lamina II):
Substantia gelatinosa consists of small neurons (Golgi type II) which have short axons. The short axons synapse with neurons of the nucleus proprius and the posteromarginal nucleus to inhibit pain transmission.
It does not contain large cells. Therefore, it does not form the lateral spinothalamic tract.
Inhibition of Pain Sensation:
1. Substantia gelatinosa cells release enkephalins which inhibit the release of substance P from the pain fibers (A-delta and C-fibers) of DRG.
2. SG cells receive excitatory impulses from the following sources for pain suppression:
a. Sensory area of the cerebral cortex via the corticospinal tract (NE).
b. Touch fibers from gracile and cuneate tracts (glutamate).
c. Raphe magnus nucleus (reticular formation) via the raphe-spinal tract (serotonin).
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