Apoptosis (2006) by Drew Berry wehi.tv, sound design Franc Tétaz

Animation exploring a signal transduction pathway that induces Apoptosis.
Published "Molecular Animation of Cell Death Mediated by the Fas Pathway", Sci. STKE 2007 (380)

Sound design is intentionally horror, as you witness a diseased cell self-distruct.
Inspired by "Alien" and "The Shining"

[masonat]

Why aren't educational animated movies to this quality more common? I love these videos, it's nice to visualize the knowledge we have but can't observe with our eyes.

[Lior]

I am dumbfounded by the complexity of this thing

[jasamcarcina]

It's two dofferent signal pathways described here. The one started with the T-cell is the extrinsic pathway, the one induced by cytochrome-c released is the intrinsic pathway. They both result in caspase-3 activation and protein and cytoskeleton cleavage.

[Chaos------]

People are impressed by the structures themselves, but what always impressed me the most was how these pieces fly around throughout the vast space of the cell and zero in on the correct areas with extreme precision, and with no visible mechanism to bring them together. What makes it even more impressive is that 85% of the contents are edited out in these videos. So what looks clear and open is really quite densely packed and extremely active.

[Unkempt_Whizard]

This is covered on the last exam in cell biology. Kind of sad to see the thing you have become so attached to throughout the semester kill itself, lol.

[GCATLiving]

The sound design on this is other worldly.

[keaganhesse]

The poor cell was bullied into suicide by the T cell smh, we live in a terrible world

[ThePhantomSafetyPin]

Really kind of sad to watch, but very impressive. How amazing our bodies are... Also is it just me or would "Death Ligand" be a great name for a band?

[zainranjha]

Exceptional work! Hats off to the entire team, particularly the animator.

[johnmacward]

Simply mind blowing what the body does.

[LCARS]

I had apoptosis once but I cured it and now I'm immortal.

[MCGeorgeMallory]

Cells are so awesome!

"Attention: You have been discovered to be diseased, and are scheduled for deletion. Please attempt to do as complete a job as possible."

"Command has been received and verified. Thank you for the notification. Now proceeding to self-destruct..."

[ErinChristeyICT]

We love this animation of the apoptotic cascade! It is a very helpful training tool for our company, which specializes in apoptosis and caspase assays. Thanks!

[KingsRoad]

All this work being done Unbeknownst to us Is simply amazing.

[williamwixon]

So mind-boggling. Again, thank you all so much for bringing this to us. It really is amazing to see a “death ligand”. ❤️ all the videos, it is so fantastically complex!

[ThrivewithSierra]

This almost felt like I was watching a horror film - creepy!! But excellent animation and really helps bring the story to life.

[wudgee]

I'm studying apoptosis at the moment in my course and having to write at the mo about cascade 8 so this is helpful to visualise things, I love this type of visual aid. Love the animation many thanks.

[sangeetaamarkarmath]

This youtube channel is still the same😊😊thanks for being consistent in all these 12 years.

[probability_density]

I can't explain it, but there's something that feels almost sacred about programmed cell death

[Luunnariiss]

This is so freaking amazing, the best way to learn it visually!