The Grignard Reaction | Synthesis of Alcohols

The Grignard reaction is the premier way of making carbon-carbon bonds in organic chemistry. In this video, we'll talk about the reaction, it's mechanism, and important things to look out for on the test.

00:00 Intro
00:35 Formation of the Grignard Reagent
01:56 Grignard structure
03:08 Reactivity of the Grignard reagent
05:04 The Grignard reaction
08:31 Examples
09:32 Reactions of esters and acid chlorides
11:46 Reactions with epoxides

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[jackryan]

Please post the mechannism of the gringard when you get time! And also the true bond struture and picture of the Gringard reagent

[emmaaguilar-torres]

hi victor please please post the mechanism of how the grignard reagent is formed. THANK YOU!!! YOU ARE SO APPRECIATED

[sarfarazmungloo]

Hi, during the Grignard run with acid halide and ester, a H3O+ issued to protonate the O- but I thought the Grignard reagent was so basic that it cannot co-exist with any acid?

[akshadnimbarte]

Can you please make a video on markonikov and anti markonikov rule

[samho]

So if a question ask for an ester reacts with grignard reagent, should I give the ketone or the tertiary alcohol as my answer, or the question won't ask like that (like will state the grignard reagent in excess)?Thank you very much

[PunmasterSTP]

Synthesis of alcohols? More like "Super important reaction that's very helpful!" 👍

But in all seriousness, I had no idea that the whole period from the early 1900s to about 1960 was the Grignard Era!