Resident Evil 4 - Pro Mode Guide - Tips & Tricks

Professional Mode for Resident Evil 4's campaign can prove daunting for some. After the success of my Mercenaries guides, many people requested that I make a general guide for Pro mode.
In this video I will explain useful strategies and tricks for improving your gameplay, I will show the best ways to deal with each boss along with key fights against the regular enemies.
This video also contains the locations of all the treasures along with the shooting gallery challenges, to help with farming money for weapons and their respective upgrades.
Speaking of weapons, I also provide you with a weapon roadmap for what you should and shouldn't upgrade based on your preferences.
This guide is not exhaustive and will not cover every single fight in the game, but I hope it explains everything well enough to help those who are struggling and perhaps teach a couple new things some players may not know about.
Below are the time-stamps of key moments so you can jump to whichever part you need, though I do recommend watching the whole guide.

00:00 - Introduction
02:10 - First Village Fight
06:36 - Canyon Fight
13:00 - Del Lago Fight
15:15 - El Gigante Fight
18:20 - Cabin Fight
19:36 - 2nd Gigante Fight
20:20 - Chainsaw Sisters Fight
22:15 - Chief Mendez Boss Fight
24:50 - The Castle
26:21 - Sword Room
28:05 - Garrador Fight
28:55 - Water Room Fight
30:53 - Shooting Gallery A
32:13 - Novistadores 1
35:53 - Praying Cultists
37:18 - Minigun Zealot
39:26 - Salazar Ambush
40:20 - The Maze
42:50 - Garrador Cage
44:16 - Ashley's Escape
45:41 - Backtrack for Broken Butterfly
46:47 - Lava Room
47:54 - Shooting Gallery B
48:33 - Knights
50:57 - Novistadores 2
54:27 - Double Garrador
56:18 - Verdugo Boss Fight
56:52 - Shooting Gallery C
57:48 - The Mines
59:44 - Two Gigantes
01:01:05 - Novistadores 3 (Caves)
01:02:55 - Mines 2
01:06:03 - Minecart Fight
01:08:07 - Salazar Statue
01:10:23 - Castle Tower
01:11:21 - Salazar Boss Fight
01:12:28 - The Island
01:12:46 - First JJ
01:17:17 - Shooting Gallery D
01:18:52 - Regenerators 1
01:20:14 - Thermal Scope
01:21:45 - Iron Maiden
01:23:10 - Wrecking Ball Room
01:24:15 - Regenerators 2
01:24:25 - Demolition Truck
01:25:59 - It Boss Fight
01:31:27 - Krauser Boss Fight
01:33:30 - Mike (Helicopter) Battles
01:38:58 - Final Regenerator
01:39:39 - Third JJ & Final Ganado Assault
01:43:23 - Saddler Boss Fight
01:47:05 - Closing Remarks & Shoutouts

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[Sarcosuchas]

If you enjoyed the video, please leave a like and a comment to help me fight the Youtube algorithm!

[kylehealey]

Always use the capacity upgrades instead for reloading your empty guns to avoid wasting ammo

[Midnight-Starfish]

Something I didn't realize as a kid playing this on my GameCube is just how useful the flash grenades are. They seriously make any group of those head parasites incredibly easy, especially that room with the six knights for the King's Grail.

[specialstagepro]

I've been playing this game since 2006, and this video just goes to show how much I still don't know about it. Great work as usual.

[haukness]

In the Two Gigantes fight, if you use the rocket launcher, you can kill the second with the lava trap. Skip the cut scene, run out of the room and back. If you are quick the money from the kill will be on top of the trap and you can get it before it despawns.

[MegaMar]

I've never thought to go back into the church after getting Ashley. 18 years and this game still surprises me.

[who]

By the time I reached the final Saddler fight on pro, i had 18 G/R/Y heals, 6 first aid sprays, and 300, 000 cash after i fully upgraded broken butterfly. I was super stingy during the entire playthrough and rarely ever upgraded my weapons (unless if I needed the ammo). I still made out like a bandit. It honestly does help to leave/return load areas and to reload checkpoints to manipulate enemy spawns in harder areas. Especially if you're dying a lot/taking a lot of damage. That's how I was able to stockpile a lot of stuff throughout most of the game.

[kylehealey]

After the first flying insect room you can use the sniper rifle to kill the watch tower guy before crossing the bridge, this will prevent the catapults from activating

[elliotjamesford]

In the water room, a good method is to have Ashley wait on the downstairs door’s left. Doing so causes the enemies to target her and get stuck on the door, allowing you to easily headshot enemies with the sniper

[bartydaman]

I would recommend this guide. Beat pro mode years ago and looking back at it, playing this game again on the switch and watching this vid I can agree that the tips and tricks given from this video can help players beat pro mode.

[davion]

I'm only 10 minutes in, but I can already tell this is an exceptionally well made guide. I already finished RE4 in all modes several times, but it's very useful to see an optimal route. Subscribed, also because of your very good Mercenaries mode guides.

[abdulqudz]

this is the best guideline i've come across. i never knew you could defeat el gigante with a few grenades and a blast from the shotgun, then slashing his plaga.
i always used the tmp with the stock and went all out.
nice one sarco!

[Xaruva]

I followed along with this playthrough the whole way. Watch a section, play a section. Learned some new things along the way. Such a great game. Arguably one of the best video games ever made. Appreciate you taking the time to make this video. Thanks dude!

[saimalishahid]

Learning to use handgun, shotgun, knife and melee appropriately can really improve odds in pro. Handgun for ranged melee setups, shotgun for crowd clearing and plagas and knife in various applications for ammo conservation. Running instead of unnecessary engagement is good too. That and using certain exploits (not necessarily glitches) can really make professional doable.

[FitzFingers]

Your watermark at the bottom right matching up with the health bar is a really cool touch to the video.

[daystrial]

I would like to thank you cause this video inspires me to beat professional. I normally play in normal mode and after beating the game and collecting some secrets or unlockable I move on the next game. After many tens of hours playing and dying and reloading check points I manage to beat it and man I was so proud of my self beating it. Thanks for the tips and inspiration your video gives me.

[Maniafig]

I'm surprised you'd skip the TMP, I'd say it's the best weapon of the game, both able to set up kick/knife combos like a handgun, do crowd control like a shotgun and it has extremely high DPS if you just unload it on (mini)bosses like a magnum. You can even use the Stock to make it stable and let it work accurately at a medium range, meaning you can substitute it for the rifle in a pinch. The game hands out ammo for it like candy as well, both from prefixed drops as well as random drops when you have about 200 or less total bullets. I usually run TMP, a pistol, a shotgun and a rifle and never really miss out on the magnum.

[minhkhoaluong]

Just got past the Castle. I've saved ammo too much that after defeating Salazar, I still have a lot of ammo to spare. Your guide is truly helpful man, saving me a lot of ammo on pro walkthrough

[X_Station_Games]

I also noticed that You can actually knife the 2 green buttons in the first cage with it

[bradl.]

26:45
"Keep your distance from type two plagas"
_[immediately suplexes]_
Got a good laugh out of that clip 🤣