Vitamin K - forms, functions, deficiency, RDA

K1- Phylloquinone- plant source
K2- Menaquinone- intestinal bacteria
K3- Menadione- synthetic

only fat soluble vitamin act as a coenzyme

Biochemical Functions
1. post translational gamma carboxylation of clotting factors II,VII,IX,X
2. Activation of Osteocalcin
3. Activation of protein C and S

Deficiency manifestation
hemorrhagic disease of newborn

RDA- 70-140 microgram

[pratikpanigrahiofficial]

0:19 Introduction
4:22 Principle role of Vitamin K
9:10 Vitamin K cycle
11:40 Required for Activation of Osteocalcin
12:38 RDA
13:05 Sources
13:44 Deficiency
16:31 Toxicity

[manukavi]

Wow...sir.... Awesome. I did my mbbs in 2003. When i saw your video in 2021, you should have been my biochemistry professor. I would have enjoyed much more. Awesome sir. It's a great service

[cmmr]

This is the first video I have found with clear concise information on Vitamin K. Thank you so much!!

[dr.damerayadaiah]

Explanation is good,
Vitamin K deficiency causes Hemorrhagic disease of the Newborn, not Haemolytic disease. Both are different diseases.
Vitamin K deficiency bleeding is Haemorrhagic not Haemolytic,
👍

[anatomyatitspeak]

Lots of respect and thank u so much sir for doing this great work .... spreading knowledge without any money deposit

[mrinmayeewarode]

Very well explained esp the cycle of vitamin k and functions, also how can vitamin k itself being helping in coagulation act in activation of anti-coagulants activation ?

[radhakrishnanravichandran]

Awesome explanation sir....best bchem professor in world ...tq sir 🙏🙏🙏🙏

[elyassarmast]

Thanks for your valuable information and also very good explains regarding vitamin k,

[stevebh]

Plants use K1 for photosynthesis, which is why it always comes with the green parts.

It's not at all clear if the body can use K1 without stripping off the side chain and converting to K2. This goes though K3 in the process (which has no side chain). A lot of K3 is poisonous which is why it is not used in vitamin pills. K1 is used by medicine because it's cheap to make.

The body makes K2 from K1 by stripping off the side chain and putting on another, and the K2 produced always has 4 isoprenes (MK-4). It's done in blood vessel walls, not always bacteria. K2 Mk4 definitely can be used to make gla proteins and clotting and osteocalcin and matrix protein. It's not clear if k1 is a provitamin for K2 or can be used without conversion. In any case you don't need K1.

Bacteria in natto and in the small and large bowel can make at K2 which is MK-4 up to MK-9. MK-7 from natto is often sold. It dissolves in fat and lasts a long time. These vitamin Ks are used by bacteria for the own anaerobic metabolism. I suspect that like K1 they are provitamins and also converted to MK-4 before your body can use it them. All these steps require removal of side chain and sticking on a proper geronyl-geronyl group (4 isoprenes) to get K2 MK4.

[mazharazizramdan]

Thank u soo much sir this is the first video that gives me alot of concept about vit k

[ghrumbijjar]

Sir g very good video all composition became clear

[neetasingh]

Sir the RDA value of vitamin k in Vasudevan is 50-100mg/day

[teamxcolt]

Sir thank u 🙏
Online classes in our college is bad
But ur classes help me understand the topics 🙏 thank u sir

[gaurabguru]

You are not a teacher or ARE THE GOD 🙏 YOU SO MUCH ❤️

[MelbourneMaster]

The name Vitamin K from koagulation doesnt stem from german, it stems from the danish word: Koagulering / koagulation. The man who identified vitamin K was the danish chemist Henrik Dam, in 1929.

[suhanakulsum]

Thank you sir. Explained very well👍
With full of clarification.. 😊Thanks again..

[ayeshajamali]

Sir your videos are very very helpful 😊😊 thank uuu sir for ur efforts

[Zerhun_markos]

great explanation
great respect and love from ETHIOPIA

[preethi.h]

Thank you sir
It's very very helpful
Clearly understand

[ramamohanaraotanuku]

You explained just like drinking water from a glass. Great sir.