Plague Inc: The Cure - Prion Mega-Brutal Guide

The prion is the first genuinely difficult Mega Brutal scenario that will likely take several restarts, even with a solid strategy in place. It's a highly infective plague with a 99.9% lethality rate, so the fatality count will be high and panic will be a constant threat. Carefully manage your quarantines with authority-preserving measures and you 'might' just pull it off.

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No copyright infringement intended. Plague Inc: Evolved copyright is owned by their respective owners which includes but is not limited to Ndemic Creations. I did not make the game (or assets) and do not claim to. I do claim recording the video and audio associated with this playthrough.

Music credit:

"Shake Down"
by Gavin Luke

#plagueinc

[sircatsmeow]

"As long as they're dying in their homes: they aren't infecting others"
Jesus Christ dude.
I mean I agree but.

[Flygoniaks]

Prion in Plague Mode: Able to slow down cure speed, but its upgrades take longer for their effects to actually work.
Prion in Cure Mode: *99% fatality rate go

[PlushMan]

The Cure: *releases for PC*
Pravus: wanna see me post a video?
Pravus: wanna see me do it again?

[heynice]

Remember. While you're enjoying this video Pravus might be having a mental breakdown trying to win against the Nano-Virus.

[furgel]

"Reassure the infected"
I'm not 100% certain but aren't prion infections literally incurable?

[AWildRaito]

Pravus is Sun Tzu's reincarnation considering how strategic he is.

[snzimash]

We all can agree Pravus is one of the best Strategy gamer in the world

[comradejeb]

I like how at 7:17 only Ireland was red and Great Britain was completely free of the plague.
Makes me think about how the UK screwed Ireland in real life.

[vincentwidjaja]

"If people would respect these quarantines, we might actually somehow be able to pull this off"

It hits different in this time

[PennsylvaniaEAS]

this dude: Prion is so furstrating

me who can hardly pass bacteria on casual: 👁👄👁

[professorbebek]

Bio weapon is twice as hard. In my last attempt I got all entire world dead and only some of them recovered and won by censorship. It was hard. but I'm 100% sure that Pravus can beat the bio weapon and I am here waiting for the bio weapon

[jc___underscore___]

13:48
Huge earthquake in France
“That’s not my fault”
Nice unintentional pun

[canalmadebyanintrovertfort]

4:47 The prion is so complex that he got infected for a second

[mileswoest]

"Where are we gonna see the worst authority loss, probably the US." 😂As an american this is factually correct

[eier]

I just took advantage of the Prion's really long incubation time. Picked up the prolonging ability (hourglass thing), the Neural Enhancers and the Reassure Infected. Then invested everything into SPEEDING through vaccine development and reducing infectivity. Won it without the use of any lockdown measures. Continental lockdowns generally seem like a terrible idea in the early game, except maybe for the Bioweapon

[Lightna]

I can't wait for the devs to make a Rebel mode for Rebel Inc. That's going to be interesting imo.

[MisterHabadu]

I've been loving your Mega Brutal Cure mode Pravus, thank you for showing us this kind of content.

[Agent-Blaze]

The part where people die in their homes is literally a secret strategy for Bio Weapon, as in there is a glitch where you win because everyone is dead, but you maintain your authority and since the number of infected is 0 the game interpret that you won

[jc___underscore___]

A fun idea would be an online version of Plague Inc where one person controls the disease and the other person tries to eradicate the other player’s disease

[pardoxia]

While it is kind of cheating, you can save your game early on and find out where the starting country is -- reload that save and then go to that country IMMEDIATELY.