A Novel Approach to Treat Parkinson’s Disease

This video is based on a news article and its source material on a novel treatment for Parkinson’s Disease. We begin by covering the basis of what Parkinson’s Disease is and what its’ current treatment options are. We then discuss how current treatment options often result in adverse health effects. The toxins that cause Parkinson’s arise from excessive conversion of the amino acid tryptophan. As such, researchers at the pharmaceutical company NTRC in the Dutch city of Oss, in the Netherlands, have developed a substance called NTRC3531-0 that inhibits the production of these toxic by-products. By inhibiting the production of these toxic by-products, dopamine production is corrected, thereby reducing the symptoms that come with Parkinson’s disease. The results seem promising, and with more research, this treatment plan can be implemented for other diseases as well. This drug is not yet available for use, and researchers are continuing to assess its efficacy. Therefore, this video is meant to provide general information, and it does not act as a substitute for medical advice. Please consult your health care provider for more information.

This video was made by McMaster students Muntaha Ahmed, Stephanie Amoah, William Douglas, Youssef El-Sayes in collaboration with the McMaster Demystifying Medicine Program

Copyright McMaster University 2021.

References:

Perez-Pardo, P., Grobben, Y., Willemsen-Seegers, N., Hartog, M., Tutone, M., Muller, M., . . . Kraneveld, A. D. (2021). Pharmacological validation of TDO as a target for Parkinson’s disease. The Febs Journal. doi:10.1111/febs.15721

Saint-Cyr, J. A., Taylor, A. E., & Lang, A. E. (1993). Neuropsychological and psychiatric side effects in the treatment of Parkinson's disease. Neurology, 43(12, Suppl 6), S47–S52.

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[a.b.c.]

Wow so much spam in the comments, Dr x blah blah blah... Guys please stop spamming when people are looking for real informations it's not good to do this, think of karma.

[jeanmcfarland]

My husband has been fighting Parkinson's Disease. It took three years to be diagnosed. By then, he was having great difficulty walking, having soreness and rigidity in his muscles, and falling frequently. He had some twitching but nothing described as tremor by the number (n>3) of neurologists we saw. We also saw a rheumatologist and a physiatrist and he went through two rounds of PT. That is another story, however. PD affects sleep, movement and mood. It has changed my husband from the most patient, attentive dad into someone who is somewhat remote and has little patience. He is more often depressed. He walks with a cane and maybe should use a walker but doesn't want to, and I don't blame him. It struck him at the peak of his career. Fortunately, he doesn't have job which requires physical labor or coordination, but in spite of this he has difficulty working. His voice frequently quits on him, even with the vocal exercises he does. He has some problems with word retrieval, which seems nearly universal in Parkinson's. The discomfort from the rigidity can be distracting. Now I have a new job, keeping my husband off disability for as long as possible, as long as he wants to work full time. I attend all appts with him and count myself an active member of kunime treatment team (www.kunimeherbs.com). I have met some amazing people. I have watched the way they have provided information and support to my husband. They have answered his questions and given him information and tools to better understand Parkinson’s. This has been a huge encouragement to me. Empowering my husband with kunime medicine and truly making a difference in the world. My husband has found that kunime medicine can reverse, reduce and even stop the symptoms of PD. I wanted to honor the fact that kunime has empowered my husband. The medicine is perfect for individuals who are currently using it, or those who have that fighting spirit. Moral of my story is don’t ever give up or don't let this disease get you down in any way. Happy Xmas 🎄❤️

[LigmusCrotum]

Hmm, what about the pathway that converts tryptophan to NAD+. Interesting that b3 vitamin relatives (NR, NMN, and even B3 itself) that increase NAD+ diretly are being studied for improving Parkinson's symptoms. What if we could reduce tryptophan and increase NAD+ shifting homeostasis to convert more of it to NAD+?

[salwashenouda]

This is absolutely needed for many patients it should come very soon in the market

[claudettetooley]

She’s talking too fast! What’s the hurry? It would be nice to hear the information.

[bennguyen]

In addition to TDO/TDO2 inhibitors (NTRC-3531-O), any thoughts on other novel approaches that may help with Parkinson's.. such as the use of Farnesol, commonly found in essential oils (citronella, neroli, cyclamen, lemon grass, tuberose, rose, musk, balsam, tolu)?

Or Braak's Theory on how boosting certain gut-bacteria (ex. Bacillus subtilis ) and stimulating the vagus nerve may help?

[NickLAnderson]

Dear God who art in heaven hallow be thy name thy kingdom come thy will be done on earth as it is in heaven give us this day our daily bread and forgive us our trespasses as we forgive those who trespass against us and lead us not into temptation but deliver us from evil for thine is the kingdom and the power and the glory forever in Jesus Christ's name we pray, amen.

[afolashaderachel]

I must appreciate Dr odija on YouTube for helping me in getting rid of Norovirus, Your product for healing stomach bug is really the best keep saving lives

[curtisjones]

They need to start testing it on humans this year 2022

[mindfulnesscoaching]

It might be good information, shame about its delivery.. Very off putting

[leostack]

I let the secretary get to me over phone at my nerouligist office