Translation Initiation in Eukaryotes

Eukaryotic translation is the biological process by which messenger RNA is translated into proteins in eukaryotes. It consists of four phases: initiation, elongation, termination, and recycling.

CAP-DEPENDENT AND CAP INDEPENDENT INITIATION PATHWAYS :

Initiation of translation usually involves the interaction of certain key proteins, the initiation factors, with a special tag bound to the 5'-end of an mRNA molecule, the 5' cap, as well as with the 5' UTR. These proteins bind the small (40S) ribosomal subunit and hold the mRNA in place. eIF3 is associated with the 40S ribosomal subunit and plays a role in keeping the large (60S) ribosomal subunit from prematurely binding. eIF3 also interacts with the eIF4F complex, which consists of three other initiation factors: eIF4A, eIF4E, and eIF4G. eIF4G is a scaffolding protein that directly associates with both eIF3 and the other two components.

The best-studied example of cap-independent translation initiation in eukaryotes uses the internal ribosome entry site (IRES). Unlike cap-dependent translation, cap-independent translation does not require a 5' cap to initiate scanning from the 5' end of the mRNA until the start codon.

[AarushiK.P]

It's 3am right now, I am pulling an all-nighter and feel so relieved to have FINALLY understood all the eIAFs in this mechanism. Thank you so much.

[ridhimagaur]

very nice video in 6 minutes you have taught us so much that we were not able to understand in 1 hour class, what an amazing teacher

[izzanare]

i have my molecular biology exam in three days thanks for explaining this better than my professor

[huzaifak]

On 5th of January 2023 I'm having my final exam for molecular Biology (I'm doing Bsc in Biotechnology and Genetic Engineering currently 5th semester final exam gonna start).
And this guy is really really something else.. I haven't understood from my teacher/professor but these lectures are so so so so well explained and easy to understand... A 100% recommended thing... Keep it up
Pray for Me, 🤲

[achalrathore]

U are the best teacher for molecular biology.... Very easily u clear such tough concepts... Thankyou so much for all the topics u teach but please upload the vedio for elongation and termination process..
Your method make these topics very interesting so please sir complete this eukaryotic translation
Thank you so much

[shortvideos]

Best molecular teacher ever 😍😍❤️
Thanku for sharing the video's, 🙏🏻😍❤️

[surayajan]

Thank you very much sir In a few minutes u have explained it so well

[misshaikh_]

Amazing explanation...you are great 👍 👌

[ankitayadav]

Ofcourse as usual awesome explanation 😀 thank you so much
And waiting for further vedios 🤗

[eissennnnnatthehaus]

Always the indian teachers who gives a comprehensive explanation about everything. Thank you for teaching us all 🫶

[anxiousaquarius]

Thank you for explaining such a complicated process in detail!

[ammarahchaudhary]

Sir plzzz upload next videos as early as possible don't take long time ,
upload two lectures in one week.

[izrai]

So very helpful!!! Thank you so much 😆

[debaswapnaray]

Thanx..it's really helpful for all students...👌

[nadineboujday]

Could you please keep the English subtitles on? It helps me understand since I'm not a native English speaker, and I translate the words I don't understand.
Thank you

[ammaramehak]

AOa sir, sir you read transcription if you read transcription where is videos of transcription elongation and termination in
eukaryote told and upload that videos also my exams are very near it, s humble request to upload transcription videos and next video early on you channel.

Be happly doing great work .

[umaasaraf]

Sir your videos are very helpful.It gives clear understanding of the topic Can you please make a video on elongation and termination of translation ?

[ammarahchaudhary]

What is circulization of mRNA why we use it, and what is their function and also told kozak sequence also

[biologicalresearch]

Do u know prof. ashish sharma sir (ex faculty of GB), your clearity of concepts make me feel like you are his student.

[sajinasasi]

Thank u sir waitting next elongation and termination part