Should you measure your oxidized LDL (oxLDL)? | Dr. William Cromwell

Is LDL harmless if it's not oxidized? How can we avoid LDL oxidation? Should we get the oxLDL test?

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Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.

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0:00 Intro
0:57 Oxidation in plasma or in the artery wall?
1:54 oxLDL vs ApoB
3:10 How to avoid oxidation
4:00 Should we get the oxLDL test?

[mattbmartin]

Terrific question at the end about where the oxLDL in samples may be coming from.

[robertk]

Is that all? I expected more from an interview with such an eminent lipidologist.

[flolou]

Fascinating discussion, please get as much time as possible to interact with Dr. Cromwell as his schedule allows, he is clearly one of the top 25 experts covering
the complicated physiology of heart disease today,

[thomasgrimm]

Excellent video, short and to the point!

[spurgendahl]

I took my oxLDL some years ago. The amount of oxidized LDL-particles proved to be low, understandably nothing to worry about. Now I understood the somewhat pricy test was of no informative value in itself. Hooray!

[chewiewins]

Glad to know I don’t need to worry about another test and continue monitoring my ApoB or at least non-HDL

[Themarcodarro]

How about the use of Cavadex/Cholrem/cyclodextrin?

[bgsharma]

If there is O2 and LDL ( or anything else including apoB or glucose or FA or Cholesterol or AA or whatever), there is always Oxidation ( combined to reduction)- Fundamental Redox Chemistry. The reaction rate is what varies and is function of multiple variables including reactant concentration, Biochemistry, enzymes, thermodynamics ( free energy) and so on.. Besides Kinetically, it is a dynamic equilibrium ( not static) so if one measures OxLDL, we will get hundreds of reading throughout the day or whenever.. Bottomline Kinetics and thermodynamics control Reaction Rates...

Since most variables except LDL or apoB concentration are beyound ones control ( One should also reduce Fe or else Fe via Fenton Reaction catalyzes or increases reaction rates), keeping Low LDL or apoB ensures least oxidation both in blood or arterial wall.. Unfortunately, we can not cut O2...

Bottomline most fancy tests are $$ making business. Lipid panel or apoB and apoA suffice some idea on body.

Hope that helps understand fundamental kinetics of OxLDL - If something is fancy, mostly nonsense...

[sabby]

I have the ApoE4 allele and cholesterol hyperabsorption, so the more saturated fat and cholesterol I eat, the higher my LDL particle count is and the higher my oxidised LDL particle count and Lp-PLA2 activity are.

However, olive oil does not taste as good as saturated fat.

So just take rosuvastatin and eat saturated fat.

Even if rosuvastatin has side effects, it will lower your cholesterol and you can live a happier life with less dietary restrictions.

[s]

Short answer with a brief justification please

[nancyk]

If sampling lipoproteins is "like looking in the garbage...." what does that mean about low Apo-b? That it is not valuable as a marker without other markers or health-stats as well? We know high LDL and low Apo-B is not predictive of CDV events. I'm confused now.

[mrdavester]

So what's the answer? .. depends?

[thirdworldperspective]

never have i ever made the first comment :D