Fast track formulation with biologics screening in a snap

As subcutaneous delivery of high-concentration
biologics becomes more popular, optimizing their
formulations becomes more complicated. Some
excipients play better with one antibody, not
another, or only help under specific conditions.
Testing formulations at high protein concentration
makes lower sample consumption and efficient
assays a must-have. High-throughput, low volume
solutions, designed for biologics, will speed up
those formulation studies. Here, we present a case
study on how to prepare monoclonal antibodies at
high and low concentrations with some common
excipients and screen for effects on quality, stability,
and viscosity.
The case study will illustrate how to produce all this
data seamlessly, allowing the researcher to rate and
rank formulations for their influence on the analyte
and to quickly narrow down the optimal excipients.