Antiarrhythmic Pharmacology

My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.

[DirtyMedicine]

Full disclosure: this is a brutal topic to learn. I did my best to simplify it. Remember to pay special attention to:

1. Cardiac action potential changes
2. Main adverse drug reaction (ADR)
3. Classification (Class 1A, 1B, 1C, II, III, and IV)

[xayisnaliemartinez]

Very Very important that Amiodarone messes with your TSH (it can cause hypo or hyperthyroidism). Appears in the questions every time

[TheAcvivek]

My mnemonic for
class IA :queen(quinidine) die(disopyramide) fast after doing cocaine(procainamide)
Class III : LOL(sotalol) till I die(ibu-til-ide, dofe-til-ide) Amigo (amiodarone)
Both class mnemonic has dying part :D so they can cause torsades de points by increasing the effective refractory period (ERP) -->> QT prolongation (Action potential prolongation)

For class IC: proper(propa-fenone) cane(fle-cain-ide) slaps the sodium channel the hardest but stabilizes ERP.

[gulzarbabarg]

Amiodarone = Am(iod)arone = iodine = Thyroid Problems.

Dronedarone = No “iod” so = No thyroid issues.

[yukyunglee]

Calcium channel blockers and beta-blockers work on the nodal action potential, so the shape of the original AP curves should be different. Thank you for another great video!

[droopingsnoot]

You could remember that beta-blockers are class II by thinking of beta being the second letter in the Greek alphabet

[xaaboopinkly]

I studied this on Uworld and it took me an entire day to master it, but you’re simplifying it into just 20 minutes, huge thanks sir!

[DannyMercer]

Christ imagine if medicine were taught like this. It might even be possible to do it in three years and be HAPPY?!

[faisalalabdally]

Na Channel blocker pneumonic for class 1 drugs...

Class 1A: DQP; Double Quarter Pounder
Class 1B: ML; Mayo Lettuce
Class 1C: FP; Fries Please

[professorcensored]

My med school professors are terrible and it's exhausting as a learner. I binge-watch Dirty Medicine after every topic we cover to actually understand the material. Thank you for helping my mental health stay afloat.

[Michael]

Additional UWorld facts:
1) Amiodaron has partial Class 1, 2 and 4 effects too. It also has an homogenous effect on K channel hence lowest risk of TdP among Class 3 agents.
2) Sotalol has partial B-cloker effect
3) B-Blockers reduce PR interval (obviously)
4) Adenosine acts on A1 receptors---->Potassium outflow--->Nodal conduction delay

[sililly]

It's so impressive how easy you and palatable you've made this topic. Thanks again

[fireandce]

Did that help? YES! That was beautiful. You are a gem, seriously. I learn way more from you than I did in my two years of med school. Any chance you could do some more drugs with us? I'd love any obgyn/repro stuff you feel like doing too. Thanks!

[riyadhatrah]

please, keep making these videos man. This is gold. This and the other videos as well.

[monzilachowdhury]

I love your lectures. Thank you:) The way I remember Beta blockers are class II by remembering that B is the 2nd letter of alphabet.

[LaoevanSVU]

Thank you for not brute forcing this and actually teaching the info!

[mattcoleman]

The reason you give glucagon in a beta blocker overdose is not because of the hypoglycemic masking. Glucagon stimulates cardiac ionotropy via a separate mechanism than beta blockers.

[staypurpleponyboy]

These pneumonics also help solidify the info:

For the K-Channel (Class III) he mentioned the AIDS pneumonic
"Kant Kure AIDS with Potassium"

Also class II - Bets Blockers
Two B's / double B's = class two

Calcium channel blockers
Verapamil and diltiazem are the only Non-dihydropyridines in the CCB class
They are "Very Different" (since they are the only two that have a significant impact on cardiac conduction / heart rate)

[mongorians]

I remember the mechanism of each of the classes though the phrase, "Never BET the Kitchen Counter". Type I, II, III, IV = Na, BETa, K, and Ca.

[sililly]

Thank you so much for taking your precious time to simplify stuff for us Dr. DirtyUSMLE.

Can you make a video on how best to recall all these fun facts from all your videos. I don't mean to sound ungrateful for everything you're doing for us🤭
Oh, I'm quadrupling the amount I'd pledged on your patreon. What I'd have paid a tutor is what I'll donate
I hope others can do the same, to show appreciation for your hard work you put in to making it easy for us.

Thank you Dr. DirtyUSMLE sir.