Acute Liver Failure | Clinical Medicine

Ninja Nerds!
In this lecture, Professor Zach Murphy will present on Acute Liver Failure (ALF). We will discuss the pathophysiology, highlighting the rapid deterioration of liver function, typically in an individual without pre-existing liver disease, and its causes, including drug-induced liver injury, viral hepatitis, and toxins. The session will transition to a digital presentation focused on the diagnostic approach, including liver function tests, imaging, and criteria for diagnosis. Finally, we will review the management strategies for ALF, emphasizing the importance of supportive care, specific treatments for identifiable causes, and evaluation for liver transplantation. Enjoy the lecture and support us below!

Table of Contents:
0:00 Lab
0:07 Acute Liver Failure Introduction
0:40 Pathophysiology | Direct Parenchymal Liver Injury
7:04 Pathophysiology | Vascular Related Liver Injury
13:16 Complications | Encephalopathy
20:32 Complications | Coagulopathy
24:34 Complications | Hypoglycemia
25:45 Complications | Increased Infection Risk
28:34 Diagnostic Approach
30:45 Treatment
35:13 Comment, Like, SUBSCRIBE!

#ninjanerd #gastrointestinal #acuteliverfailure

[armin]

I'll tell my kids that Ninja Nerd was my favourite professor in med school

[Owusuus]

Professor Nerd, you’re changing medicine, making studies and understanding of medical conditions more understandable to students and providers than it has ever been. Thank you so much for the great works. You’re an amazing blessing to generations ❤

[summermazur]

Love that you're making more liver videos! After the brain, I feel it is the most amazing organ. Sadly, all of its functions aren't talked about nearly enough.

[obianujuokafor]

How u made that look so simple but complicated when it was taught in class…thanks so much I understood everything perfectly

[amrkhaled]

the clinical medicine series is the best thing that ever happened, keep it up please Zach!

[TasnimAlwattar]

Best professor ever ❤️❤️, it is very rare to see such comprehensive lectures for free on youtube

[ANGEL-dnpr]

You’ll be one of the reasons why I’ll be a good doctor <3

[MambaCool]

This is great!! You and your team are special individuals sent from heaven. God bless you

[beccamckee]

Your lectures are great! You have helped me through my AGACNP program!! Keep them coming.

[sajiruddinsk]

Thank you so much, Jarur, Murshidabad WB India🇮🇳.

[annasiddique]

Luv this, explained well
Could you also do a video on chronic liver failure

[Bipolar_Spike]

I thought getting LD was somehow my fault, I just racked my brain trying to figure out what exactly did I do. A few months ago I was told that I have this by Autoimmune Hepatitis. I thought it was the psych meds I took. Back in 2012, I recently relooked at the bloodwork and I had elevated liver enzymes. Yet, I have never been clean or sober. I have 29 years and 2 days clean from meth. I'm glad I quite that long ago and never had to go back to it. The alcohol is a different story. In December 2019 I was diagnosed with NAFLD, and figured no big deal, It regenerates itself. So, I wrongly thought. So much for that. By November of 2020 it advanced to NASH, stage 1. By that time, I decided I ought to change my PCP to a hepatologist which turned out to be a good idea. In September of 2020, I no longer could feel anything. So, dumb me in all my 'wisdom' thought I ought to add alcohol to the mix. This continued until January of 2023. Not too smart on my part. Almost every day I drank. This went on for 2 years and 4 months. So, in fact I did in fact cause the cirrhotic liver. The Autoimmune Hepatitis is very rare and it is even more rare for men. As women make up 90%of the patients. Cirrhosis was not even on my radar. I just assumed I would die of congestive heart failure or some cancer. Cirrhosis was just something skid row drunkards get. What a shock I was in for.

My MELD score was 16 then dropped to 14 then down to 8 and now back up to 10. I am afraid to drink or take drugs. I know all too well that would end my life a whole lot sooner. We all know why are going to die someday, sooner or later. In addition, I am closely monitored as I have bloodwork done every other Friday. If I do I know all too well that I would sincerely disappoint my medical team.

[Bipolar_Spike]

Acute on Chronic Cirrhosis of the Liver. NOT fun at all. I am in pain almost every day. Sometimes it hurts a lot and sometimes not so much. I am waiting for a referral to a pain management doctor. I can hardly wait. I really need it.

[messionepack]

Please do more clinical medicine videos, been looking for liver videos for a long time but to no avail on youtube. Thank you for this video, simple and detailed.

[osamahegazy]

great lecture as always, paracetamol toxicity also can induce DILI ?

[shahiramohammadi]

I learn more than university from you Zach you are the best teacher in world ❤❤❤

[doctor]

Thank you so much! You really help me in my internal medicine exam 🫶🏻🫶🏻💘

[nathanaelnaranjo]

Can you get acute liver failure from alcohol alone? And if so how soon can you diagnose acute liver failure from blood tests

[Dr.optimist]

Sir from which book you are giving lectures?

[kapilkhatri]

Almost 1 year ago i suffered from hepatitis A acute liver failure now can i take creatine supplement? Plss answer