EGFR signaling | Cell Communication

The epidermal growth factor receptor (EGFR) pathway, meticulously detailed in numerous journals including Science and Nature, reigns supreme as a master regulator of diverse cellular processes. Initiated by ligand binding, EGFR dimerizes and triggers a cascade of protein phosphorylation events involving key players like Ras, PI3K, and MAPKs. This intricate network controls myriad functions, including cell proliferation, differentiation, survival, and migration. Dysregulation of this pathway, often due to mutations in EGFR itself, fuels the development and progression of various cancers, highlighting its immense clinical significance. Understanding the complex interplay within the EGFR pathway remains a central focus in cancer research, paving the way for targeted therapies and improved patient outcomes.

@SU2C @nature @mdanderson @cellsignaldotcom

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