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Stem cell effects of consuming sea buckthorn extract - Video Abstract ID 186893
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Video abstract of original research paper “Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects” published in the open access journal Clinical Interventions in Aging by Drapeau C, Benson KF, Jensen GS.
Purpose: The aim of this study was to evaluate the effects of a proanthocyanidin-rich extract
of sea buckthorn berry (SBB-PE) on the numbers of various types of adult stem cells in the
blood circulation of healthy human subjects.
Study design and methods: A randomized, double-blind, placebo-controlled, cross-over
trial was conducted in 12 healthy subjects. Blood samples were taken immediately before and
at 1 and 2 hours after consuming either placebo or 500 mg SBB-PE. Whole blood was used for
immunophenotyping and flow cytometry to quantify the numbers of CD45dim CD34+ CD309+
and CD45dim CD34+ CD309- stem cells, CD45- CD31+ CD309+ endothelial stem cells, and
CD45- CD90+ mesenchymal stem cells.
Results: Consumption of SBB-PE was associated with a rapid and highly selective mobilization
of CD45dim CD34+ CD309- progenitor stem cells, CD45- CD31+ CD309+ endothelial
stem cells, and CD45- CD90+ lymphocytoid mesenchymal stem cells. In contrast, only minor
effects were seen for CD45dim CD34+ CD309+ pluripotential stem cells.
Conclusion: Consumption of SBB-PE resulted in selective mobilization of stem cell types
involved in regenerative and reparative functions. These data may contribute to the understanding
of the traditional uses of SBB for preventive health, regenerative health, and postponing
the aging process.
Purpose: The aim of this study was to evaluate the effects of a proanthocyanidin-rich extract
of sea buckthorn berry (SBB-PE) on the numbers of various types of adult stem cells in the
blood circulation of healthy human subjects.
Study design and methods: A randomized, double-blind, placebo-controlled, cross-over
trial was conducted in 12 healthy subjects. Blood samples were taken immediately before and
at 1 and 2 hours after consuming either placebo or 500 mg SBB-PE. Whole blood was used for
immunophenotyping and flow cytometry to quantify the numbers of CD45dim CD34+ CD309+
and CD45dim CD34+ CD309- stem cells, CD45- CD31+ CD309+ endothelial stem cells, and
CD45- CD90+ mesenchymal stem cells.
Results: Consumption of SBB-PE was associated with a rapid and highly selective mobilization
of CD45dim CD34+ CD309- progenitor stem cells, CD45- CD31+ CD309+ endothelial
stem cells, and CD45- CD90+ lymphocytoid mesenchymal stem cells. In contrast, only minor
effects were seen for CD45dim CD34+ CD309+ pluripotential stem cells.
Conclusion: Consumption of SBB-PE resulted in selective mobilization of stem cell types
involved in regenerative and reparative functions. These data may contribute to the understanding
of the traditional uses of SBB for preventive health, regenerative health, and postponing
the aging process.
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