Hyperthyroidism Overview (causes, pathophysiology)

"Hyperthyroidism is defined as elevated Thyroid Hormones (TH) in circulation. Thyroid hormones are important hormones in fetal development and also metabolism. So high thyroid hormone levels as you can imagine will amp up metabolism to a point where it becomes pathological. Hyperthyroidism and thyrotoxicosis refers to the same thing really. However some define hyperthyroidism specifically as increased synthesis of thyroid hormones where as thyrotoxicosis refers to the clinical syndrome of excess circulating thyroid hormones, irrespective of the source. In this video hyperthyroidism will mean high levels of thyroid hormones in circulation causing the signs and symptoms of hyperthyroidism.

Understanding the physiology of the thyroid gland, the hypothalamic, pituitary thyroid axis is important to understanding hyperthyroidism

thyrotropin-releasing hormone (TRH) stimulates the synthesis and secretion of thyroid-stimulating hormone, TSH), which acts at the thyroid to stimulate all steps of TH biosynthesis and secretion. The THs thyroxine (T4) and triiodothyronine (T3) control the secretion of TRH and TSH by negative feedback to maintain physiological levels of the main hormones of the HPT axis.

In hyperthyroidism there is elevation of circulating TH this means there will be a negative feedback loop causing a decrease in TRH and TSH"

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[armandohasudungan]

🎥 DON'T JUST WATCH, LEARN ACTIVELY! TRY THE QUIZ! 🤓

[gloriag]

Crazy how all y’all out in the comments here cuz of a test of some sort & then there’s me: trying to understand what I’ve been diagnosed with 😬 best of luck to every single one of you.

[howtomedicate]

Great drawing! It makes your explanation so much clearer! Thank you 👍

[Reversely]

Apparently I have a high free T3 5.71 pg/mL (2.8-5.2), I'm a bit scared but I'll go get checked tomorrow. I am praying I don't have hyperthyroidism.

[surajchaubey]

Excellent description and very useful information for quick revision. Would love to see a detailed lectures on topics like this...

[amatullah.rodaina]

Thank you a million times over!
Your videos have been a great help, may God shower you with many blessings, we're forever grateful for the superb content you offer us

[rfqnnda]

this is so understandable and interesting especially for me who an audio visual type in studying, and very helpful for my daily task thank you

[Lucerozeus]

quality video as always. Thank you Armando.

[amirza]

5 O'clock in the morning... Getting ready for my Pathoanatomy II Exam which includes also the Endocrine System... What else to do then to watch the amazing
Armando Hasudungan
on 2X Speed. Thx for your amazing videos.

[thyroidhealing]

Love your video! I have started following a diet for 90 days which will completely cure Hypothyroidism if I follow it the right way. It may take longer than 90 days dependant upon how severe my condition is. I am on thyroid meds for 13 years now and I can't wait to take them off any live my life freely with full of energy and zeal!

[ScuzoidMelee]

A month ago I could lift my legs out of bed. After a lot of struggle, finally got to the hospital. Elevated T4, very low potassium, clean MRI, clean auto-immune disease results. None of the 4 doctors I saw a month ago mentioned iodine, so I assume my levels were appropriate? Went on Methimazole for a month, but at least 20 of the past days one of two scenarios would happen. In the morning seemingly random muscle groups (although never biceps, back, or shoulders) would experience near paralysis from the moment I woke for about 3-5 hours. These muscles wouldn't ever be in pain until I tried to move joints associated with the muscle. I'd be able to move these joints 1/10th or so of their normal range before they'd just hit a wall where no matter how much I forced it, the joint wouldn't move any further. The other possibility for the day was in the evening, seemingly random muscle groups (although never the back or abs) would behave as if I went very heavy at the gym on these muscles the day before. I'd have full mobility with these muscle groups, they just were incredibly fatigued. Highly elevated heart rate throughout all of this, although it's certainly possible this elevated heart rate existed for at least a short time before the hospital visit a month ago. Blood pressure has been perfect throughout. Currently waiting on a new set of blood work and a call from the endocrinologist. Given that the reason I searched this video is because the paralysis happened again this morning two days after my last Methimazole, seems likely that medication did nothing for me. Male, 39.

[alhanoufa]

I have a CD about the etiology and pathophysiology of hyperthyroidism. So thank you a lot 👌

[aliciapoh]

Thank you so much, this is really useful! Your videos always help me to understand better.. so much better!!

[vishwasd]

Best way of teaching.... easily clears the concepts

[thomas.]

why do people shy away from negative feedback when it is crucial to balance in life

[rigrentals]

Coincidence i was studying pharma topics on hypo/hyper-thyriodism... I think not. God bless you sir. cant wait for next video.

[dilanramazan]

Thank you Armando for making complex topics easy to learn! 🫡🙌🏻

[michellelumiguid]

Hello, here to make pathophysio of our cae, thanks for making this video!

[shyamalyashodarasrikantha]

Very excellent presentation

Thank you❤

[iirupadha]

You really make it all come easy, thankyou so much!