Is aging linear or non-linear?

Now, as a biochemist, it won’t come as a surprise when i say i like proteins. In fact, i have dressed up as proteins more than occasion.. Proteins are the molecular machines, the enzymes, the structural components, the dynamic elements of the cell. They do stuff. And that’s a good thing, not just for our cells, but also for us understanding aging. If protein X goes up or down with age, this could provide us with actionable information. Now, this idea is not novel - in fact, one of the earliest videos i made on this channel was about undulating changes in the human plasma proteome with age. While that is still a great paper, and we’ll come back to it later, a new paper has come out with and used a much larger dataset, to create a proteomic aging clock to predict mortality and risk of common-age related diseases. Let’s take a look at what this is all about and what we can learn from these findings. And then compare there results with another new paper that looked at multiple biological variables to observe non-linear changes?

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Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

[paulhindle]

The overall theme of my anti-aging strategies is to convince my body to continue taking care of itself, I am telling it to ignore what nature is telling it to do as it gets older. Physical exercise tells it I am still able bodied, good nutrition provides the needed resources, and I attempt to supply all the beneficial molecules that promote health. Our bodies are well equipped to do the rest after these conditions are met.

[LuciousKage]

Please Do video about the Telomere extension Pill they gave to
Would be nice to see your take on that.

[SlamminGraham]

I think it's pretty clear that aging is a non-linear process, I mean just look at the mortality curves. They accelerate with time, as with an exponential function. With exponential functions, the rate of change is proportional to the current population, which causes the characteristic "exponential blow-up" which is all too familiar to everyone from high school math. What's more interesting, though, is if the new data says that the rate of change itself can alter in intensity once a human body reaches a certain threshold (i.e. the proportionality constant of the exponential curves suddenly changes), or if it changes from an exponential curve to a linear curve however briefly, or if something else happens which suggests that aging is more than simply accumulation of damage, or risk of death. If so, what causes the sudden changes, the "kinks" in the curve, which start each new regime of aging? If they are that sudden, then it implies a fundamental mechanism causing the sudden "jumps", and such mechanisms should be able to be controlled, no matter what they are. If they are caused by DNA or RNA changes which change production rates of proteins, then great -- then we've understood what we need to examine to cure aging. If it something else, great too, because we will have narrowed our understanding of the root causes of aging hopefully quickly.

[deltasquared]

Growing up is like walking up a hillside, getting old is falling off the cliff near the top of the hill

[_c_y_p_]

many interesting questions! We need better standardization of data.

[peterz]

Thank you! I recall that the Conboy lab plasma exchange work (ref. 2020 -2022 papers) looked at certain proteins and gene expressions in old vs younger plasma. Seems like a lot points to the extra cellular environment as playing a role in aging.

[NofLongevityQuest]

Do you know of a frequency chart which shows the most common ages of death?

[TheValiantZero]

Aging is easy to solve:
1. Fix telomerase so they don't fail at their maintenance job.
2. Fix (AGEs). Stop the body from being affected by them, or create a 24/7 repair mechanism.
3. Fix oxidative stress occurrences. Stop the body from being affected by them, or create a 24/7 repair mechanism.

That's it, three steps. There's no need to focus on anything else. We need human trials, and we need them now.

[austinmackell]

I just checked with Joe Biden and it turns out it's non-linear.

[_c_y_p_]

Did you just say you like proteins? 💙🥰