Pathogen evolution in a vaccinated world | Andrew Read

Vaccines alter the immune landscape experienced by pathogens, and hence their evolution, by targeting subsets of strains in a population, reducing the number of fully susceptible individuals, and creating or expanding classes of semi-immune hosts. The great success of vaccination against the acute childhood occurred without being undermined by pathogen evolution, but those diseases were easy targets: natural immunity was evolution-proof; all vaccination needed to do was to induce something very similar. Pathogens now under assault by vaccination are different: their natural infections induce leaky, often strain-specific immunity that usually wanes. Vaccines against these diseases will induce immunity to which natural selection has already found solutions. Evolutionary analysis is particularly warranted where vaccines are leaky, target subsets of strains or virulence determinants, involve novel technologies, or relax selection against virulence. Vaccination has been a great benefit. Continuing past successes requires evolutionary considerations at all stages of vaccine design and implementation.

Andrew Read,
Alumni Professor in the Biological Sciences,
Director, Center for Infectious Disease Dynamics,
Evan Pugh Professor, Pennsylvania State University
Pathogen evolution in a vaccinated world

Andrew Read, Alumni Professor in the Biological Sciences & Director, Center for Infectious Disease Dynamics at Pennsylvania State University, visits the ASU Center of Evolution, Medicine and Public Health, to lecture on the subject of Pathogen evolution in a vaccinated World.

[pfschuyler]

Apparently the CDC and WHO failed this course.

[markman]

Thank you citizen from earth for doing your due diligence and researching things for yourself. Hats off to you.

[hiddengemzny]

If you're here you're a free thinker 💯

[beikehanmu]

I have a feeling this talk would not be allowed in any place today

[cambridge]

Isn't this applicable to todays 'leaky' covid vaccines?

[greggoldberg]

If you are here you should look up Doctor Reads paper. The evolutionary epidemiology of pathogens during vaccination campaigns, terrifying.

[johnoverstreet]

01:00:38 - 01:01:30

This whole video is fascinating from beginning to end. Surprisingly, the Q&A was informative and to the point. This little exchange will be of interest to people coming here out of curiosity about some of our newest vaccines being deployed against novel pathogens frequently mentioned in the news.

[LifeSizeBox]

This video reminds me of a new experimental gene therapy that people are taking today.

[libertysprings]

Sadly I learned about all this following the introduction of 3 Mareks vaccinated heritage chickens to my large diverse flock of heritage chickens, all different breeds and sources almost all non-commercial. 90% of the unvaccinated birds died the first year (50+ usually leg paralysis followed by death in a week or so, though sometimes they just dropped dead with no other symptoms), and I have been breeding the small number of survivors the past 2 years to attempt breeding for resistance. I still have the vaccinated hens too though (all 3 survived and never had any symptoms even though they were likely the source) so I just don't breed their offspring.

[Joy]

As new more virulent strains appear we still ignore treatments and add booster shots. 😔

[paprikaahmedTruthAddict]

What about the evolution of the immortalised HEK cells?

[psalm]

It is almost Christmas 2021, a week ago I thought the light at the end of the tunnel was here. Omicron is extremely transmissible. I thought we would see herd immunity by March. Watching this has convinced me this may not be true. Dear God, I pray I'm wrong. Lord have mercy!

[trishmarck]

At around 26 mins in the vaccination of children may put an unvaccinated person at great risk…so this begs the question will vaccinating children against Covid do more harm??? Very interesting presentation

[GP-wueu]

When he says “hot” does he mean more transmissible or more deadly? Or both?

[paprikaahmedTruthAddict]

Think your Graphene oxide delivery systems your programmable operating matter for targeting and snipping inserting gene therapy will never be discovered by the common man?

[globalgovind]

27:56 does this apply to the coronavirus too? Pls explain

[peteplayz-norskgaming]

Is he being pressured by something/someone? Penn?

[kellikelli]

ANSWER ~ You go back to nature for the remedies and cures 😉 *