Scientists Discover Protein That Causes Aging

Duke NUS Scientists Discover Protein That Causes Aging

A research team lead by Anissa A. Widjaja recently published in Nature that inhibiting interleukin-11 extends lifespan by nearly 25% in 75 weeks old mice (55 years of human equivalent age.) Team has discovered the age causing protein. Of course there are more proteins and mechanisms that contribute to aging, however, inflammation is central part of these processes. IL-11 with age start increasing in amount contributing to visceral fat accumulation, muscle wasting, and metabolic irregularities. Let's review the study together.

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URL list from Friday, Jul. 26 2024 14:44 PM

Interleukin Linked to Muscle Loss, Fat Accumulation of Aging | Duke Health

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan | Nature

Inflammation | DrBeen

Omega-3 polyunsaturated fatty acids inhibit IL-11/STAT3 signaling in hepatocytes during acetaminophen hepatotoxicity - PMC

Scientists discover protein that causes ageing - YouTube

[dr.abdulrhmanm.h.]

I am immunologist have phd in clinical immunology and I very benefit from your lectures in immunology thank you so much❤❤❤❤

[cynthiaabu-samrah]

Liking-in with a hello to @Drbeen Medical Lectures and all KoolBeens!

[colleen]

Wow, this is very exciting. Great video.

[taiwanjohn]

Interesting. I think there was a study in the last few years that showed an extension of lifespan for Omega-3s. This paper on Il-11 offers a plausible mechanism for the benefit shown with Omega-3.

[jimmattox]

??? Has anyone studied how vitamin D3 reduces IL11

[robinhood]

From the Field to the Laboratory: Air Pollutant-Induced Genomic Effects in Lung Cells.
First published online February 18, 2016

"The nine genes that showed significant changes in gene expression in response to ambient air were
associated with immune and inflammatory responses - - - Two of these genes were also modulated in
response to ozone exposure, namely IL12B and IL11."

"For the ozone exposure, both the IL12B and IL11 had increased expression."

Does this not mean; air pollution is increasing the process of ageing -> inhibiting IL11 reduces the effect of air pollution on ageing?

[LilFella]

Fascinating studies Dr Mobeen Syed. Thanks for sharing!!!

[MaryKDayPetrano]

There's a study about how risperdal can cause breast cancer in women who had a prior lesion, via the Jak-STAT pathway. Your video is so very interesting.

[klondike]

I'm going to increase my sardine intake. Luckily they're one of my favorite foods, and low on the food chain.

[Earwaxfire]

I've seen publications suggesting that EPA and DHA inhibits IL-11 pathways and extends lifespan. I've heard dolphin researchers suggest that that C15 saturated fatty acid can also increase lifespan through other pathways. Can you discuss these ideas?

[ushasiroy]

Being a beginner in understanding the cellular pathways i am quite curious to know how the il-11 pathway is related to ros generation as it is known reactive oxygen species results in ageing and how antioxidants and il-11 inhibitors can work together to make humans more healthy.

[nbrown]

Oh my, I don't know if you have seen the movie "In Time" but if this comes to pass we will not all get it I bet. There are many trying to shrink the population so I doubt a life lengthening process will be allowed to be used by the masses.

[SantiagoHHC]

This information is very interesting! It is good that you provide some suggestion about what natural approach to inhibit IL-11 progression. That is Omega 3. The issue is that omega 3 is a family of various fatty acids; ALA, EPA and DHA, just to mention some. It would be an excellent addition to clarify the type of omega 3 most effective. Don’t you think?

[robertthompson]

Diagnosed with fatty liver. I have begun eating a salad with sardines and hard boiled eggs to bring protein up to 50 grams. Amazingly i dropped 5lbs in past week. Now I can attribute some of the weight loss due to Omega 3 of sardines not just caloric restriction. At 70yrs am the oldest OG under the barbell at local YMCA. Does addition of Essential Amino Acids supplement to a wholesome diet decrease inflammation? Thanks for Intel.🏋🏻‍♂️🏊🦊

[logic]

How very interesting, thank you for presenting this study to us all. 🙏

[CharlesMacri]

Excellent discussion of Inflammation!! Thank you!

[richieheetebrij]

Apparently an odd chain fatty acid such as C15 best omega 3 significantly

[furiousdoe]

Thanks for the Omega 3 tip … 🙏🏽, the researchers will not be so pleased with it like me 😂

[wealthychef]

So how do I go about inhibiting my IL-11?

[MadMaltMasher]

Thank you long time listener here. I'd love to buy you a coffee in person. So, .you are saying we should eat avocados 🥑