Psilocybin may ‘reset’ the brain to help manage treatment-resistant depression

Robin L Carhart-Harris, Leor Roseman, Mark Bolstridge, Lysia Demetriou, J Nienke Pannekoek, Matthew B Wall, Mark Tanner, Mendel Kaelen, John McGonigle, Kevin Murphy, Robert Leech, H Valerie Curran & David J Nutt "Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms." Scientific Reports 2017.

Scientific Reports is the open access home for all science that is methodologically, analytically, statistically and ethically robust, as judged by a rigorous peer review process.

[waynedavis]

Psilocybin mushrooms, DMT and LSD has been quite therapeutic for me.
I was diagnosed with severe depression and mental health issues, not until a friend recommended golden teachers mushroom for spiritual and mental gratification. I’ve been well ever sincefor about 4 years now.

[jimwoodman]

I have been depressed for a long time, but after taking mushrooms few months ago, l feel much happier and highly motivated and my ADHD gone, lost a ton of anxiousness and had a few epiphanies about how I should live my life. I decided to buy an ounce for backup, but haven’t yet felt the need to take any more since then.

[MartinsDesign-csiq]

I could remember several years ago l suffered severe depression and mental disorder. Was actually addicted to cigarettes and alcohol. Not until my wife recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 11 years totally clean. Shrooms are God- sents

[loganturner]

Psychedelic is the answer to most severe anxiety and depression. The use of magic mushrooms completely helps one get over depression and makes you feel like yourself.

[fheucei]

Psilocybin mushrooms have augmented my feeling of what life is really all about, changed my perspective of living to a whole different level, seeing the beauty of nature in its abundance whilst also making me aware of what surrounds me and it's importance.

[joshuajasonma]

Its funny that these psychadelics that helps people their well being are considered as taboos while that liquid bottle are considered as norms. Spread the awareness

[PetMatheus-uc]

I’ve had a truly positive and amazing results with mushrooms. It was incredible!

[shokotatsuno-p]

The experience I got from taking shrooms as a whole was spectacular, I felt completely supported.

[Greg.Olson]

Psychedelic mushrooms really healed me years back. Totally got rid of depression, anxiety and illicit pill addiction.

[howareya]

I just took .2 of a gram today, haven't touched any in 10 years. Been depressed as long as I can remember. I can very much feel a difference. It took me right out of my own head and helped me concentrate more externally.

[timothytikker]

In my first psilocybin session (3.8 gr), I felt as if my mind was a PC going through defragmentation. Then I experienced what felt like as series of OS updates: changes of perspective, sometimes even every few seconds. When I reported this to my therapist, she said that a number of her other patients had used exactly the same language to describe their experiences. In any case, I found that it fundamentally and definitively brought my chronic depression to an end.

[danihatton]

Coming to this video having just accompanied my mum to the current psilocybin clinical trial for depression that's going on in the UK.
She has suffered for 40 years, and in the taxi home after her dosing we laughed, chatted, made plans, admired the passing London scenery. She said she felt like she loved herself for the first time in her life. It's truly groundbreaking. I'm crying writing this.

[JoseLopez-tlyt]

Psilocybin mushrooms saved my life honestly. They helped me see the pure beauty in life, and made me realize how dumb it would be to take myself out.

[Mellowcanuck]

I've been in a wheelchair for twenty six years. In all that time I have learned to close off parts of myself. That limits my emotional range. Makes it easier to introvert. Three sessions with psilocybin and my brain is waking up. There's therapy there. It forces emotions on you. You just need to relax, chill out, let your mind flex and stretch.

[RIFFRAFF]

I micro dosed for a year straight after a major depressive episode. It totally set my head right. I'm talking a 10th of gram a day.
Much better than SSRI meds.
Now I'm just normal crazy.. Love ya!!

[alistairclark]

I have personally cured my own depression with microdosing in the same way I managed a severe head injury when I was younger, by breaking habits of thought. Our thoughts and behaviours, actions and reactions are merely habits formed from repetition. Psilocybin in low doses basicly throws you 'off your game' just slightly so your mind stays in the present moment. Depression is the habitual, repetative dwelling on negative pasts in combination with the habitual, repetative expectation of a negative future. Psilocybin merely breaks the repeated habit by keeping your focus on the present moment without expectation for the future breaking habitual thoughts giving the brain opportunity to form new habits. But you have to 'steer the ship' so to speak and realize you have to conciously choose the new habits you form.
It's also very helpful to practice consistently changing your routine, take inconvenient paths instead of convenient ones. It's also very helpful to delay satiating your cravings to break habitual reactions. None of this works automatically, YOU are at the helm of your mind or you will be in for an out of control ride and inevitably a crash.

[Mr.NoPrints]

My son's mother died in a car accident back in December, Very rough time for us, My son was 7 when she died he is now 8. But 3 weeks after the funeral I was such in a depressed state it was horrible, the grief n pain was off the charts.. 3 weeks after the funeral I ate 3gs of shroom.. Prior to this was about 6yrs since last shroom experience. Needless to say I went thru a psychedelic cleanse, I weepd n cried and pray n pray etc.. I came down off my psychedelic exorcism which it seemed so lol..Next day I felt much better, I let go of the grief and the depression was much lighter.. Will say the experience helped me cope with my son's momma passing a great deal. They are without a doubt a great Medicine!! Love you all!

[chyzybj]

Psilocybin is an ancient and powerful medicine. It is amusing that “modern” medicine is only now trying to understand what Indigenous people have know for a millennia.

[ThorntonArtStudio]

You can feel this happen. People call it the afterglow. Quite the opposite of a hangover. These are 100% worth the research.

[svensubunitnillson]

we need more trials focused on elderly citizens, activation of new patterns is encouraging.