Bacteriophages: Is medicine going viral?

Bacteriophages have been a hot topic in the science community in recent years. This video looks at the structure of bacteriophages, their mode of action and their potential to treat bacterial infections. Alternatives to antibiotics are desperately needed as multidrug resistance in bacteria becomes a more pressing issue.

This video was made by McMaster Demystifying Medicine Students Michelle Armstrong, Mohammed Cassim, Tania Namrud, Suraj Brar and Daniela Carvalho.

Copyright McMaster University 2019.

References

O’neill JI. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. Rev. Antimicrob. Resist. 2014 Dec 11;20:1-6.

Sharp, R. Bacteriophages: biology and history. Journal of Chemical Technology & Biotechnology 76, 667–672, 10.1002/jctb.434 (2001).

Calendar R, editor. The bacteriophages. Springer Science & Business Media; 2012 Dec 6.

Bertozzi Silva, J., Storms, Z. & Sauvageau, D. Host receptors for bacteriophage adsorption. FEMS Microbiol Lett 363, doi:10.1093/femsle/fnw002 (2016).

Chan, B. K., Sistrom, M., Wertz, J. E., Kortright, K. E., Narayan, D. & Turner, P. E. Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa. Sci Rep 6, 26717, doi:10.1038/srep26717 (2016).

Wunderink RG. Turning the Phage on Treatment of Antimicrobial-Resistant (AMR) Pneumonia. American journal of respiratory and critical care medicine. 2019 Aug 27(ja).

Furfaro, L. L., Payne, M. S., & Chang, B. J. (2018). Bacteriophage therapy: Clinical trials and regulatory hurdles. Frontiers in cellular and infection microbiology, 8.

[mithraapple]

River ganga had that property from centuries

[Shheistmcgregor]

great informative video . i enjoyed it very much, thanks....