Homotopic, Enantiotopic, Diastereotopic, and Heterotopic Protons

In doing NMR spectroscopy, we must be able to predict chemical shifts for a variety of protons. When comparing specific pairs of protons, we can assign them a few different relationships, those being homotopic, enantiotopic, diasteretopic, and heterotopic. Let's see what these words mean and what they indicate for chemical shift!

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[mariewolf]

You are an angel. I've been trying to study my chem book for over 2 hours now and wanted to cry and you explained it so much better than an entire chapter in less than 6 minutes you sweet beautiful man.

[leynanguyen]

my professor couldnt save his life to explain this. This makes so much more sense now thank you!!

[minioohs]

My orgo chem exam is in a few days. Thank you so much for your clear explanation!

[leulgetachew]

Me: Watches 2 hours lecture on this form my Uni professor
Also me: comes to YouTube confused AF
Prof Dave: Talks for less than 10 mins
Me: Wants to fight everyone that had the audacity to dislike this video

P.s Thank you so much for helping us and giving us the time to write you tube comments

[asadsiddiqui]

Taking Organic Chemistry 2, and holy crap that was a beautiful explanation for something I was panicking a little about!

Thank you so much, professor dave!

[theblackvod]

you have saved my midterm tomorrow you beautiful genius man

[laurel]

Thank you so much. Tomorrow, I have an NMR examination. Your video saves my life🙈🥺💪

[ethankrenos]

been a while since I have been on this channel, congrats on all the success Dr. Dave!!! Thanks for all the help over the years!:)

[noone]

Good video helps me Understand Chemistry

[S_R_B-bl]

God bless you, my guy! Maybe now I actually won't fail my chem exam tomorrow

[captainclown]

Great Video but I feel it should be mentioned that the chemical shifts described in the video are only correct for achiral solvens. In chiral solvens Enantiotopic groups will also have a diffrent chemical shift.

[J-lr]

Wow, thanks a lot about your explantation!
It's really clear!!!

[esmfamil]

My prof just posted 3 hours of lecture trying to explain this. Some people shouldn't be teachers smh. Thanks prof Dave!.

[TheObsesionOtaku]

i`ve being figthing against this concept for ages and now i understand omg

[hala]

THX u so much u explain better than my teacher 😂🙏🏻🙏🏻

[PunmasterSTP]

Diastereotopic? More like "Dang good information about a tough topic!" Thank you so much for sharing.

[indirapandey]

Can you please make content in Hoye’s method.

[OMGshinyobject]

Im not sure if i just missed it but you should say that if a CH2 lies on a C2 axis they are also homotopic

[rutha]

im scared by how little this made sense why can't I just get this Jesus :(

[carolinedeasy]

Is this correct: homotopic if no original chiral center and no new chiral center created when switching one of the hydrogens for a variable group, enantiotopic if no original chiral center but a new chiral center is created through replacement test, and diasteriotopic if there was original chiral center and doing the replacement test yields a new chiral center?

and homotopic if there was an original chiral center but no new chiral center is created through replacement?