15.4 Homotopic vs Enantiotopic vs Diastereotopic | Organic Chemistry

Chad breaks down how to distinguish whether the relationship between two hydrogen atoms in a molecular structure is Homotopic, Enantiotopic, or Diastereotopic. Homotopic protons and enantiotopic protons are chemically equivalent and will each result in a single signal in an H NMR spectrum, while diastereotopic protons are not chemically equivalent and will result in two signals in an H NMR spectrum. Chad specifically shows how the replacement method can be used to assign the proper designation.

0:02 - Homotopic Hydrogens
1:16 - Enantiotopic Hydrogens
3:15 - Diastereotopic Hydrogens
5:37 - 3 Examples of Assigning Homotopic, Enantiotopic, Diastereotopic

Happy Studying!

[SaadKhan-ulzy]

you have done more for me in 10 minutes than my professor and TA have done over a week’s worth of classes, thank you so much

[DoubleBourbonBaconCheeseBurger]

First time anyone ever talked about this and it made an ounce of sense omg. Thank you so much...

[kawaii_strong]

This is super helpful! The textbook we use (Klein) goes more into using visualization/models to figure out the relationship (ie: enantiotopic can be reflected in a mirror, homotopic can be rotated 180 degrees) but doesn't go into chiral centers and using those to help make a determination. Thank you!!


Edit: Just realized you must also use Klein, since the video title uses the textbook chapter/section number that correlates to this topic (15.4). :)

[poisonivy]

beautifully explained. thank you. i love you

[gogoi]

You explaination is amazing man, keep it up

[mhiretgirma]

Loved the examples very helpful and can you also show us how you make the videos as well I find it really interesting. Thank You

[tyroonblack]

You're a legend, 10 minutes and everything is clear!

[nry]

God damn, I was struggling with it until I found your videos man .
You are a HERO ❤

[jessieriddle]

I have never heard such a succinct and detailed explanation :) Thank you so much!!

[abdulelahabdulaziz]

Thank you so much! you are a life saver.

[Aziz-edux]

Thanks a lot! This helped tremendously!

[jnorwich]

Such a great video, thank you! One showing ring systems would be great:)

[hassanacademy]

Nice video.. lots of love for ur effort from india 👍

[raymondfaf]

But for the example you used for homotopic atoms, isn't that example also enantiotopic?

[THECHEMOPHILIC]

Sir explain this,
I am having this doubt from a long time
Carbon carbon single bond can rotate freely, therefore on average both Diastereotopic hydrogens will have overall same environment,
Hence should give only one signal?
But why they give different signal?
Plzzz reply

[saanakhairi]

@9:43 why are the methyl groups chemically equivalent to each other? Because if u rotate the molecule 180 degrees u could tell it was rotated. Someone please explain

[besoler]

for 8:44 the compound does not have a chiral center why is it diastereotopic you use the z test to make the compound a chiral center is that right?

[imtehcumseh]

Subscribed. Thank you for your great video.