Microbial Products Affect the Hallmarks Of Aging: Mitochondrial Function (Part I)

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The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes and/or microbial products. The bacterial metabolite, LPS, increases during aging, and it negatively impacts mitochondrial function, thereby demonstrating a role for microbial products on one of the Hallmarks of Aging, mitochondrial dysfunction.

[danno]

Very good information! Thank you — much appreciated— I have subscribed.

[OneDougUnderPar]

Very interesting, and well presented, thank you. Interestingly, much like learning new vocabulary, hearing terms used in similar but different contexts really helps cement the learning and improve understanding. I've been reading about ROS on a couple of different scienceblogs in regards to insulin sensitivity and weight gain, and now I have a better understanding in both contexts.

I appreciate you sharing your knowledge, thank you.

[luckyhanger]

I followed as much as I could, very technical. I really enjoy your channel and as I get older the subject of aging theory interests me more and more. Can you suggest any good references, particularly texts, on aging theory?

[sandram]

Zhang preprint study showed LPS levels <1 EU/ml in young people, increasing to 2-3 in older, so 4 EU/ml in centenarians is in line with that trend. Why is the comparison young person endotoxin level of 6 EU/ml so different in the other study?

[ottoavila]

Any studies on effect of arginine/citruline on endothelial cells? This has greatly helped my body heal from aging

[myrealnews]

Is LPS a factor that hasn't been identified in parabiosis or plasma replacement experiments?

[edwhite]

Are there any approaches to reducing LPs?

[ivanandreevich]

Obvious question - what has your cardio been in that time period?

[andrewf.]

If ketogenic diet inproves the mitochondrial functions, is it safe to say ketogenic diet with help you as you get older?

[main___name___main___name]

This is all very nice, but we will be dead and decomposing when the clinically tested and approved solution to prevent the inevitable degradation with aging will finally become available for general consumption.