TWiV Special: Coronavirus update with Mark Denison, MD

Pediatric infectious disease physician and coronavirologist Mark Denison joins Vincent for a discussion of COVID-19 and SARS-CoV-2 with an emphasis on antiviral therapeutics.

[edvardcxoi]

Thanks again. Our entire family listens and discusses each episode.

[MrOzzyCam]

Thanks as always Vincent. Good talk Dr Denision. This talk was well worth listening to.

[victorrichenstein]

Your clear thinking science is such a pleasure to listen to and learn from. Just as relevant 6 months later.

[Live.Vibe.Lasers]

Best virology info on the net I've found. Can't wait for the IgM/IgG lateral flow antibody tests to be widely available. Ironically, we'll probably be buying them from Wondfo, a Chinese company.

[GhostPrefix]

We need more of this - fascinating observations and insights !

[hisoyami]

20min great podcast and episode as always

[身赤-ww]

Thank you so much for providing us with this valuable information! Great listen!

[bistrakamburova]

About protease inhibitors used in FIP, he should look at GS-441524. GC376 is the older one. In tissue culture they both give identical results, however, efficacy against naturally occurring FIP appears to be far greater with GS-441524 than with GC376. GS-441524 is what is used in the Facebook group.

[earllofland]

This is awesome! Great resource for understanding virology and immunology for my medical studies

[marchanson]

I love this podcast! The virus came from the Head of Zeus... Exactly.

[teganmares]

Do you ever study extraordinarily healthy people? Those who seem to resist infections from viruses?

[tbainbridge]

Have a look into a study performed on RSV using prophylactic treatment Lactobacillus gasseri strain LG2055. Reducing both replication and cytokine storm of IL-6 and TNF-a, study was done in mice. As for the replication inhibition, possibly it's worth looking again to nature to find how Lactobacillus gasseri strain LG2055 does this.
Also I think the bacterial defence against Phage like using it's own Cas-9 restriction enzyme (cutting DNA), do you think there would be a Pharmaceutical way to induce such an action in our own cells (without giving us cancer) to chop up the viral RNA after entry?
Just ideas.

Btw, im just a Pharmacist, but I did a science degree way back, and loved virology, 3rd podcast I have listened to, excellent channel and content. Subbed.

[manfredadams]

This is COVID-19. SARS was COVID-2. What happened to the 24/7 news coverage of the other 17?

[jacobkammer]

What role does the protease enzymes play in the life cycle of the virus. I know in HIV they cut the polypeptide chain leading to activation. and is the exonuclease a separate protein from the RNA dependent RNA polymerase?

[iashakezula]

Just wondering for those with mild symptoms, have we figured out how long do they stay positive or when they become negative ie from the onset of fever not unless they are tested for SARS Cov2

[valerieriggs]

Any idea what is responsible for the relatively low number of fatal cases in children? Normally a viral infection would produce a "U" shaped distribution, with very young and very old being the largest cohorts. Correct? Apologies if you covered this already!

[davoforrest]

Are the innate immune systems of younger age groups somehow more able to cope with the SARS COVID 2 than older age groups?

[easymoneymusic]

Do the tests identify CORVID-19 strain specifically, given that most people have coronaviruses of all variations. The only way you can determine the numbers of coronavirus 19 carriers is by distinguishing them from the others. If the tests don't to that, then how do they arrive at the conclusion that people have caught this specific virus?

[edvardcxoi]

At this point I'm with the herd becoming used to living with it and using the model Dr. Denison proposes (and for the very reasons he supports his proposal with.)

[wd]

People with Emphysemia HAVE to breath deeply ... Somebody, just taking a deep breath as opposed to a non deep breath .... lands in the nose or it lands in the lung You do the math .... I think it could be just that simple, along with the load of virus received. This is why I think we all need masks, all the time, every time--for some time. All of this on top of spacial distancing and hand washing etc ...