TWiV 889: COVID-19 clinical update #110 with Dr. Daniel Griffin

In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa.

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I’m Vincent Racaniello, Earth’s Virology Professor.

I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

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#microbe #viruses #coronavirus #pandemic
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[patriciagiles]

Thank you Professor Vincent and Dr. Daniel Griffin as always for the clinical updates.

[HotelPapa]

The objective of the Zoe project when mentioning altered symptom profile (or really a complete symptom profile) is not differentiating between the variants. It's about getting GB officials to modify their information when to suspect Covid and get a test.

[lesfaby]

Links for this episode
03:45 Hospital admissions during
Omicron and Delta variant outbreaks (Lancet)
06:20 Viral load in unvaccinated and vaccinated individuals (Nat Med)
12:04 Predictive Capability of symptoms in children (Clin Inf Dis)
12:26 Comparison of antigen tests (medRxiv)
21:53 Incidence of Myocarditis after COVID19 and
non COVID19 vaccination (Lancet)
26:05 Steroids during viral replication phase (Resp)
27:03 Paxlovid efficacy and safety (Pfizer)
27:05 Paxlovid for standard risk patients
32:55 Fluvoxamine and Outpatient Management (JAMA)
37:23 Sabizabutin efficacy and safety (Veru)
41:01 Colchicine and lack of benefit (Lancet)
42:16 SARS CoV 2 prevalence in Africa (medRxiv)
43:46 Reducing risk over the holidays
44:27 Contribute to ASTMH fundraiser at PWB
Dr Griffin’s treatment guide
45:14 Letters
45:21 Eben 6 year old periocarditis is it long term
47:27 Charlie 75 year old covid with risks and antivirals
49:18 Jessie 85 year old covid and Paxlovid
51:21 Philip Dengue survivor and dengue vaccine
Second illness can be more deadly

[aliceobrien]

From ireland good to see ye, thanks for all ye do just love when I'm awake to be part of yer podcasts vincent look forward to all

[janakingking]

Thanks Vincent and Daniel! I stay up every Friday night to get caught up.

[corrinaclark]

Thanks Vincent and Daniel. From Queensland Australia 🙂

[booklover]

This breakdown on treatment of Covid is so vital and informative. I am sending this to my brother and his family. This episode should be mandatory viewing.

[patriciahoke]

For me, at this point, this is the quote that really matters:

"We need all hands on deck. If the providers out there are not educating their patients, are not advocating for their patients, are not communicating the urgency of responding in that window, yeah, our hospitals are gonna start to get busier."

[danpolier]

This talk is so incredibly informative, Dr. Griffin. Thank you on behalf of everybody listening to you. You are a hero.

[Logotic]

Listening to these two guys talk about COVID is always a highlight of my week.

I do hope, though, and I say this with utmost and enormous respect, I hope it won't be a highlight of my week a year from now.

[markgivens]

Glad you mention Zoe and emerging treatment possibilities. Also intrigued on the dengue topic. Prayers for peace and health in this holiday season.

[marklemont]

Thank you! Very specific and informative.

[Peepers]

Great quote, and always look forward to this great informative, entertaining channel.

[ghogsten]

Thank you, happy Easter or Passover. Thanks for all you do.

[SupremeODMG]

My 1 1/2 year old son has been sick it seems for months he has congestion and stuffed nose. We caught covid back in late December of 2021. 😢 the peditrician has not done any serious testing they keep assuming he is teething or ear infection and just give amoxcillin. He has all his teeth and no ear infection, this has been constant...it scares me to death.

[lawrenceralph]

Thanks for the excellent update. Happy Easter.

[offthehook]

Not sure Vincent will see this. But this update isn't yet up on Spotify. Not sure if that's an oversight.

[elinannestad]

About a week ago a 16 year old boy died of myocarditis 2- 3 weeks after 1st Pfizer dose, here in NZ. We will never know if the vax caused it but it is thought likely. It must be incredibly rare, and his parents surely understand this - they make a point of saying they do not want their child's death to put people off getting vaxxed, or to be used by anti-vaxxers.

[t.c.s.]

Did the Lancet article separate out myocarditis seen in young men post vaccination? Sadly, I've lost confidence in The Lancet since their rather humiliating Surgisphere debacle.

[patriciagiles]

Any Twiv regs know which episode discusses Dengue with ADE & FC receptors?