The Future of Genomics: 10 Bold Predictions

#Genomics2020

The 2020 NHGRI Strategic Vision culminates with 10 bold predictions for human genomics by 2030, narrated by Pulitzer Prize-winning author, biologist and physician Siddhartha Mukherjee. Crafted to be both inspirational and aspirational, the predictions are intended to provoke thoughtful discussions (and even debate) about what might be possible in the coming decade.

Credits:
Videographer/Executive Producer: Alvaro Encinas, NHGRI
Animator: Ernesto Del Aguila III, NHGRI
Writer/Assistant Producer: Prabarna Ganguly, NHGRI
Music: Zachary Utz, NHGRI

[genometv]

10 Bold Predictions:

1. Generating and analyzing a complete human genome sequence will be routine for any research laboratory, becoming as straightforward as carrying out a DNA purification. (01:37)
2. The biological function(s) of every human gene will be known; for non-coding elements in the human genome, such knowledge will be the rule rather than the exception. (01:44)
3. The general features of the epigenetic landscape and transcriptional output will be routinely incorporated into predictive models of the effect of genotype on phenotype. (01:49)
4. Research in human genomics will have moved beyond population descriptors based on historic social constructs such as race. (01:57)
5. Studies that involve analyses of genome sequences and associated phenotypic information for millions of human participants will be regularly featured at school science fairs. (02:05)
6. The regular use of genomic information will have transitioned from boutique to mainstream in all clinical settings, making genomic testing as routine as complete blood counts. (02:14)
7. The clinical relevance of all encountered genomic variants will be readily predictable, rendering the diagnostic designation ‘variant of uncertain significance (VUS)’ obsolete. (02:22)
8. An individual’s complete genome sequence along with informative annotations will, if desired, be securely and readily accessible on their smartphone. (02:30)
9. Individuals from ancestrally diverse backgrounds will benefit equitably from advances in human genomics. (02:38)
10. Breakthrough discoveries will lead to curative therapies involving genomic modifications for dozens of genetic diseases. (02:44)

[DaveE]

What’s the vision / prognosis for microbiome research, protein one and while I think it’s in its infantry, the virome? What will be faccinating is when we can combined all those.