Part 3: Haemoglobin - Structure, Synthesis, Types, and Function

In this series we shall discuss the NeedToKnow physiology and pathologies of the Red Cell (RBCs/Erythrocytes)
Part 1: Haematopoiesis - how blood cells are produces
Part 2: Erythropoiesis reticulocytes, erythropoietin, hypoxia-inducible factor, and the structure and function of RBCs
Part 3: Haemoglobin - Structure, Synthesis, and Function
(other parts pending)

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[needtoknowmedicine]

00:00:27 – Defining Haemoglobin what it’s composed of
00:00:54 – Structure: Haem – protoporphyrin + iron
00:01:36 – Structure: Globin + types
00:03:04 – Haemoglobin synthesis
00:03:20 – Synthesis: location
00:03:43 – Synthesis of protoporphyrin – the rate limiting step and vitamin B6
00:04:40 – Synthesis of haem -
00:07:09 – Types – what causes the variability?
00:07:50 – Types – foetal/fetal haemoglobin (HbF)
00:12:21 – Types – Adult haemoglobin (HbA) and normal variant HbA2
00:16:00 – difference in affinity between HbF and HbA
00:16:57 – Function of haemoglobin
00:17:16 – Function – oxygen transport
00:18:26 – Function – oxygen: the oxygen-haemoglobin dissociation curve
00:22:54 – Function – changes to the oxygen-haemoglobin dissociation curve
00:23:20 – right shift of the oxygen-haemoglobin dissociation curve
00:24:13 – The Bohr Effect
00:25:10 – 2, 3-DPG (2, 3-diphosphoglyceric acid)
00:25:25 – left shift of the oxygen-haemoglobin dissociation curve
00:26:32 – factors that cause a left shift of the oxygen-dissociation curve
00:26:53 – why HbF causes a left shift
00:27:07 – left shift: carbon monoxide poisoning
00:28:40 – Function – carbon dioxide transport

[sushmithaj]

It is a beautifully detailed video with a comprehensive and easy to understand explanation! Truly grateful for such an amazing video!

[dj.jenishdave]

Nice content 👍!!loved it. Well explained.

[lubnajan]

Loved how comprehensive it is. Subscribed already. 👍
But you should have discussed hemoglobin synthesis in details :(

[bellokhaeerat]

Thank you very much nice and easy to understand.

[switchedon]

Great presentation & easy to follow.
What temperature is considered low or high?
Same for PH?
I'm curious because patients with body temperature regulation issues seem to be more prone to anxiety and shortness of breath