Best ivermectin meta analysis

Ivermectin for Prevention and Treatment of COVID-19 Infection

A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines

Background

The antiparasitic ivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials.

A 2018 application for ivermectin use for scabies gives a direct cost of $2.90 for 100 12-mg tablets.

Most trials were registered, self-funded, and undertaken by clinicians

We assessed

Efficacy of ivermectin treatment in reducing mortality

Chemoprophylaxis

Data sources

Databases up to April 25, 2021

Sifted for studies, extracted data, and assessed risk of bias

Meta-analyses were conducted and certainty of the evidence was assessed

GRADE approach

GRADE (Grading of Recommendations, Assessment, Development and Evaluations)

Reproducible and transparent framework for grading certainty in evidence

100 organisations worldwide officially endorsing GRADE

GRADE has four levels of evidence, certainty in evidence

very low
low
moderate
high

Decreasing confidence

Risk of bias

Imprecision

Inconsistency

Indirectness

Publication bias

Increases confidence

Very large magnitude of effect

Clear dose-response gradient

Residual confounding is likely to decrease rather than increase the magnitude of effect

Data sources

24 randomized controlled trials

N = 3,406 participants

Ivermectin reduced risk of death compared with no ivermectin

Meta-analysis of 15 trials (n = 2,438)

Average risk ratio 0.38

Moderate-certainty evidence

(Confirmed using DerSimonian–Laird method and Biggerstaff–Tweedie method)

Ivermectin verses no ivermectin in hospital patients

Ivermectin, 2.3%

No ivermectin, 7.8%

Ivermectin prophylaxis reduced COVID-19 infection

3 trials, n = 738

Average reduction 86%

Low-certainty evidence

(due to study design limitations and few included trials)

Clearly favored ivermectin use

improvement

deterioration

Severe adverse events

Rare among treatment trials

Evidence of no difference was assessed as low certainty

Conclusions

Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin.

Using ivermectin early in the clinical course may reduce numbers progressing
to severe disease.

The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.

Current NIH recommendations

there are insufficient data to recommend either for or against the use of ivermectin for the treatment of COVID-19

The sample size of most of the trials was small

Various doses and schedules of ivermectin were used

Some of the randomized controlled trials were open-label

Patients received various concomitant (confounding) medications (e.g., doxycycline, hydroxychloroquine, azithromycin, zinc, corticosteroids)

The severity of COVID-19 in the study participants was not always well described

The study outcome measures were not always clearly defined



Ivermectin for preventing and treating COVID‐19 (April, 2021)

[janetkelly]

Lovely comment by a YouTuber who asked why doctors wouldn’t use the effective and cheap drug ivermectin. As she said “it just doesn’t make cents”

[alatsaf]

The government of Indonesia has ordered the Indonrsian pharmaceutical company to produce a massive amount of ivermectine to save the people of Indonesia. I think they are very wise!!!

[jassonsw]

Very encouraging and the Oxford University study into Ivermectin promised in February and cancelled for unknown reasons is now finally going ahead. If it shows Ivermectin to be effective then there should be a public enquiry into why this was delayed.

[MrJohnny]

I am a 65 y.o. male and was diagnosed with COVID back in jan. 2021. My symtoms were being tired, loss of appitite, head pain and congestion. I was asked by the doctor at the clinic if i would take a pescription, and i said yes, as long as its not something polititions are pushing. I was given one for an antibiotic and one for a two dose Ivermectin. After the second dose of Ivermectin my symtoms vanished completly!!!

[diancassidy]

So happy this is now published. I know these physicians have been trying for many months to have this meta analysis published. We now have a treatment for Covid that cannot be denied!

[thekatephillips]

Funny how the best reporting in the last year has come from doctors, professors, podcasters, retired medical personnel and citizen journalists…
NOT professional journalists!

[theperfectbeing]

Even if there's insufficient data, there's virtually no downside to using it at all. It's dirt cheap, already used all over the world and seems to have some positive interaction of a variety of levels from the docking component to protease inhibition. The saying of never ascribe to malice what can be explained due to stupidity doesn't apply when there's hundreds of billions of dollars on the line for companies that have knowingly bought up most of the worlds governments influence.

The same companies that shut down HIV treatment medication production in Africa in the 80s because they were using their intellectual property to produce a no name version of the meds for 1/20th the cost (at no profit). They were willing to let tens of million of Africans die over a patent they barely even used in the first world. What makes anyone think these companies who have the largest class action lawsuits of all time over death/complications from medications against them, should be considered trust worthy in regards to their incentives is beyond me.

[edpiv]

About 6 months ago there were a few positive studies. Everyone ignored them.

[radovankohlmayer]

Thank You Dr. Campbell!
Please stay on the topic of Ivermectin.
Many lives still can be saved.
I Mask+ protocol helped my family to deal with COVID infection.
Thank You again

[evolutionislife]

Lets face it, anyone still listening to the WHO are probably not too bright.

[prof.crastinator]

Skewed by a flawed Egyptian study that made up data and was retracted. Take that study out and it’s nada.

[madeleinesuzette]

For those of us who have been deemed medically unfit for the vaccine (by medical professionals).. This is good news!! And I find it irresponsible by the medical profession that this is not discussed in general or alternatives researched for those of us in this category!!

[musicalbard]

you did a video about ivermectin in use against covid in Mexico that was very well done/carried out and it showed a much higher rate of success.

[pedrogorilla]

Thanks for being courageous and talking about this despite the pressure against it. I appreciate your integrity.

[patrick]

Just got covid symptoms last Thursday.\ Tested on Saturday and took Ivermectin Saturday and Sunday. Thursday and Friday had extreme fatigue and aches and pains in legs. Sunday those symptoms gone completely. Now just a head cold and am taking mucinex and Vitamin D. Me 75 yr old U.S. male with diabetes, hi B/P, and HI Cholesterol . I thought I needed some extra help. No after effects.

[droneracer]

There's no profit margin, so our politicians won't want the contracts for their friends, they will wait until there is a more profitable alternative.

[garymyers]

Lots of other studies show the efficacy in numerous trials. No excuse for the exclusion except for $ in pocket of Pharma and social manipulation due to hyped up fear

[jaymorgan]

On a side note - what's the difference between between a conspiracy theory and the truth ?
Answer: about a year.

[Comrade_Mauri]

Doctor are you going to remove this video? Or talk about the revised study? It seems that data has been redacted…

[nicolpeacock]

Well done on a million subs dr 👏 amazing 😍