Build and Deploy a Biotech AI Tool: Python, Next.js 15, React, Tailwind, Modal, Typescript (2025)

Everything (including GPU's) is free, and no biological background is needed, since I'll walk you through all the theory needed.

TL;DR / Simpler Version
DNA is like a long code made of A, T, G, and C. Small changes (mutations) in specific parts of this code, like in genes responsible for preventing cancer, can increase a person's risk of developing the disease. For instance, if an 'A' appears where a 'T' should be at a particular spot, that's a mutation. These changes can vary in how harmful they are, and we'll build a tool to analyze these different variations' harmfulness.

Features
🧬 Evo2 model for variant effect prediction
🩺 Predict pathogenicity of single nucleotide variants (pathogenic/benign)
⚖️ Comparison view for existing ClinVar classification vs. Evo2 prediction
💯 Prediction confidence estimation
🌍 Genome assembly selector (e.g., hg38)
🗺️ Select genes from chromosome browsing or searching (e.g., BRCA1)
🌐 See full reference genome sequence (UCSC API)
🧬 Explore gene and variants data (NCBI ClinVar/E-utilities)
💻 Python backend deployed with Modal
🚀 FastAPI endpoint for variant analysis requests
⚡ GPU-accelerated (H100) variant scoring via Modal
🎨 Modern UI with Tailwind CSS & Shadcn UI

📖 Chapters
00:00:00 Demo
00:03:50 Theory
01:42:08 Cloning the Evo2 repo
01:45:52 BRCA1 notebook
02:05:33 Running on Modal
02:42:30 Backend
03:08:10 Thresholds and confidence
03:32:40 Deploying the backend
03:35:30 Frontend
03:50:46 Genome assembly fetch
04:10:40 Chromosomes fetch
04:40:27 Genes search fetch
05:14:07 Gene details fetch
05:30:25 Gene sequence fetch
05:43:30 Gene information card
05:56:39 Gene sequence card
07:17:14 Known variants card
07:18:15 Known variants fetch
08:14:20 Mutation analysis call
08:30:17 Variant comparison modal
09:05:30 Variant analysis card
09:57:35 End notes

[andreastrolle]

Biotech is in rapid growth, and so is AI. So let's create something using both, not seen before on YouTube.
P.S. Feel free to let me know what I can improve in the video. Teaching style, etc.

[carlelarsen]

Every video you drop makes 100s of startups obsolete. Insane stuff keep them coming!

[arhaansayeed]

More biotech + AI content please!
This was a great project!!

[muhammadain]

I am subscribed to 300+ channels but i must say that your channel and the content you provide is the best and most unique among all the channels. Thank you for your service to the developer community.

[maxippacheco]

This tutorial is actually insane, keep posting please!!!

[front-shadow]

A very entertaining project and very well done, I hope to see more projects like this focused on other areas, such as AI tools, for other professions, etc, a hug and keep it up, I subscribe!

[akshaydhiman]

This is awesome, You are the only one who provides the full picture and understanding of an application using latest techstacks. Continue the good work.
Also if possible please include RunPod serverless maybe as your videos provides insights on the costing part of the deployments as well.

[OnlyJavascript]

this channel is gonna explode soon. long live Andreas.

[KaranSinghedb]

You made content like a super genius. I Loved it, please continue these type of unique projects.

[notesaccount]

More biotech + AI content!!! This was good!!

[nazmulhossain]

Bro thanks for these videos I am really grateful. I have learned a lot from your video's. ❤
Please keep making amazing and next level projects. I don't think there's much people in YouTube with these great projects.😊

[wego-k]

Well done man. You are just so amazing and unique. Absolutely unique.
No one even comes close to the things you do on YouTube and talk less combining with python. God's Speed 😊👏🏻👏🏻

[abdelrahmanmostafa]

The app idea is innovative I really like it, keep up the hard work <3

[OniJechto]

This is amazing, The quality and ambitiousness of this channel is immense. I love the theory and crash course to biology.

[DjangoElRey]

Great explanation and super interesting - I'll watch it! 😮❤

[SitabjaBiswas-fv]

everry video you make is a startup idea and a hackathon winning project and solves real world issue

[dronamrajurahul]

Seriously just Wow🤯..Every video is total 💎

[harshavshah]

Your content is awesome
Keep uploading videos like this

[aaditya_ai]

Really appreciate your efforts of putting such good content on here Andreas !!

[JulesAM]

Andreas you're a genius! Keep the up the good work