Serotonin Syndrome Explained (Serotonin Toxicity)

Serotonin syndrome, also known as serotonin toxicity is a potential life threatening condition due to excessive serotonin levels in the body. In this video we look at the symptoms, diagnosis including Hunter Serotonin Toxicity Criteria and treatment.

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Video Timestamps:
0:00 What is Serotonin Syndrome?
0:25 Serotonin Syndrome Pathophysiology
2:03 Serotonin Syndrome Symptoms
3:26 Serotonin Syndrome Risk Factors
4:08 Serotonin Syndrome Diagnosis (Hunter Serotonin Toxicity Criteria)
5:16 Serotonin Syndrome Treatment

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Disclaimer: Please remember this video and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.

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For more medicine videos consider subscribing (if you found any of the info useful!):

Video Timestamps:
0:00 What is Serotonin Syndrome?
0:25 Serotonin Syndrome Pathophysiology
2:03 Serotonin Syndrome Symptoms
3:26 Serotonin Syndrome Risk Factors
4:08 Serotonin Syndrome Diagnosis (Hunter Serotonin Toxicity Criteria)
5:16 Serotonin Syndrome Treatment

[stevelindsay]

WELL DONE. THE BODY TEMP SWING HAS ALWAYS BLOWN ME AWAY.
IT CAN BE A 100 DEGREES IN HERE AND I'M STILL SHIVERING AND SHAKING, FREEZING MY ASS OFF.

[Badboybonsai]

I had serotonin syndrome caused by citalopram, I spent a month in a coma and now have epilepsy. Ruined my life. Lost my job and driver’s license.

[samr.]

I was on 6 different meds that affected serotonin production when i decided to experiment with Lsd. I didn't know about serotonin sydrome and i had 14 seizures in 2 hours and almost died.

[Rat_Queen]

I had my SSRIS increased due to higher anxiety
1 day later, I had the runs, headaches, trembling, muscles twitches, sweating…it was mild but still, I needed at least a week to recover at home 😮

[michelebunting]

I think my mom had this last week. It was awful. She’s on 2 or 3 antidepressants. One benzodiazepine. And other meds. She was vomiting, pail, heart palpitations. Had falls and passed out once. It’s no joke!

[mssee]

I think I once had (a mild case of) this. Took DXM with beer while using 5-HTP and mirtatzapine regularly as I didn't know about the interactions. Felt very dizzy, jittery, sweaty and disoriented for like a week.

[clementine]

SSRI have this too. I was going to the birth of my nephew. I was rushing and I definitely took a double dose of my medication that day by mistake. The lights had a halo around them and it felt like the room was tilted. I was shivering and couldn't get warm. I didn't end up having an emergency situation but I was glad that I was in a hospital that day.

[dust]

i might’ve had this one time i smoked like three blunts and i was also on a new dose of lexapro i got super sick, hella pale and my mind was super disoriented and i felt like i was gonna die
but i was not greening out, trust me i’ve never in my life thrown up from smoking too much weed and my tolerance was very high, i know what greening out feels like and it’s never made me physically ill like that

[sj]

I was taking phentermine for weight loss and fluoxetine for ADHD. I had no idea that they couldn't be taken together. My doctor who prescribed was aware of my other medication taken but mentioned nothing about it. I felt so out of it, like a zombie, everything was going in slow motion. I'd also have these intense random flashbacks/hallucinations.
I trusted my doctor before I had done my own research to find that my medications were not compatible with eachother.

[narcissisticidiot]

I took alcohol and Xanax (what I was told) and I believe I had this, I still have residual effects like a strange feeling every time I yawn, and a strange feeling that’s hard to describe in my stomach

[mitacestalia]

Uh, I might need to check to my doctor. I've been having heart palpitations, nausea, want to vomit and lost appetite, and twitching legs too.... It's been going for three weeks too...

[shinjiikari]

Oh shit, looks like I need to talk to my psychiatrist, how the hell did he not pick up on all the concerningly overlapping symptoms I've mentioned in relation to my medication?

[dafni]

I took Valerian root + Duloxetine and was so sick had to go to er. Severe weakness, fever, sweating, vomiting etc it was awful. The Activated Charcoal I took at home helped alot. Unfortunately they didn't help me the hospital at all except for an anti- nausea pill. It was a joke

[melankoIi]

had this yesterday for the second time lmao it feels hard to breathe for days afterwards

[sirseas]

So I’m taking some medication and notices some twitching in my legs mainly, but also in my shoulders and stomach from time to time. But that’s it. It’s a twitch like you have when you’re sleeping and then jolt back awake. It happens when I’m in bed mostly

[helenalovelock]

My daughter (21 years) had this within hours/days of being put on starting dose 20mg of Citalopram.

[tggraham]

An unknown combo to be careful of is the OTC supplement 5HTP and onedestrone (zofran) os dangerous. But taking along with buspar, and hydroxizine even worse. Be sure you talk to your doctor before adding any supplements. I made this mistake and it was a terrible!

[michelleelle]

This has happened to me I’m having really bad anxiety because of it and I don’t know how to get rid of it I feel like nothing is helping and my doctors can’t see me til Wednesday

[edgarcasey]

How about mdma and using 5htp to help r
Heal the serotonin receptors