CAR T Cell Therapy and Lupus

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In this video, Dr. Donald Thomas, clinical rheumatologist and author of The Lupus Encyclopedia, shares the latest science behind this emerging lupus therapy and its promise of drug-free remission.

Special thanks to our sponsors Tin Rocket, Blue-eyed Crow Studio, 7-Minute Cinemas and PhRMA for their generous support in making this video possible.

Note: Since the video taping (as of April 2024), additional data have been published, and at least 43 SLE patients have been reported treated with CAR-T cell therapy. Almost all developed mild, easy-to-treat cytokine release syndrome (most common symptom was fever).
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It's amazing that there's a curative treatment of a chronic disease like lupus

yassirmohammad
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Since the video taping (as of April 2024), additional data have been published, and at least 43 SLE patients have been reported treated with CAR-T cell therapy. Almost all developed mild, easy-to-treat cytokine release syndrome (most common symptom was fever). 

Therefore, Dr. Thomas retracts his statement in the video regarding Novartis' CAR-T therapy. Thus far, their results appear to have similar safety and efficacy as other products). 

kaleidoscopefightinglupus
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Exciting, wondering if there are any updates on this.

speakup
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Great talk! How did the anti-SSA antibody patient on cd19 CART benefit from therapy, if they did not have reduction in anti-SSA antibodies? (28min mark)

lighto
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Hi, Great video. Does Dr. Donald have an opinion on CD19 antibodies or CD19 T-cell engagers? I know CD19 CAR-T has most data, but may be restrictive to patients. thx!

lighto
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I have a question

How does the b cells come back after 90 days if cart cells are still in the system trying to eliminate them

shalevsaada