Memory and the Hippocampus

This neuroscience video will help you to understand the structures/anatomy and the functions of the hippocampus located within the medial temporal lobe of the limbic system. The trisynaptic circuity is the pathway of memory transmission in the hippocampus which is explained in the video.

The hippocampus is part of the hippocampal formation which includes the dentate gyrus, parahippocampal gyrus, and hippocampal gyrus. The hippocampal gyrus contains areas such as the entorhinal cortex and subiculum, which are both vital in the flow of information through the hippocampus.

The hippocampus is divided into CA1 to CA4 regions which stands for cornu ammonis. This is the area of the brain which has a very important role in memory due to the high levels of NMDA glutamatergic receptors located in the CA1 Schaffer collateral neurons. The synaptic plasticity of these neurons heavily relies on long-term potentiation (LTP) induction to allow the strengthening of declarative memory (which includes two types of implicit memory such as episodic and semantic memory – Facts and events).

The trisynaptic circuit receives sensory input from the cortical regions of the brain which enters via the entorhinal cortex. This projects via the perforant pathway to the dentate gyrus, then to the CA3 region via the mossy fiber pathway to future travel to the CA3 neurons through the Schaffer collateral pathway. Finally, this signal is outputted from the subiculum to the rest of the various areas of the brain such as the Fornix (which can loop back to the entorhinal cortex).

If the sensory input is very strong and is repeated multiple times, LTP will be induced to increase synaptic connections. This allows the trisynaptic system to occur more rapidly next time.

#Memoryformation #neuroanatomy #youcanlearnanything

What is the hippocampus? What does the Hippocampus do? Where does Memory and Learning occur in the brain? What is the hippocampus structure? Where is the hippocampus located? What is the function of the hippocampus? What does the hippocampus mean? How does your memory work?

We will answer all this in this video so let us know how we do!

Copyright Mentions:
• Xu, X., Sun, Y., Holmes, T. and López, A., 2016. Noncanonical connections between the subiculum and hippocampal CA1. Journal of Comparative Neurology, 524(17), pp.3666-3673.
• Henry Gray (1918) Anatomy of the Human Body Book
• Hippocampal Neurons Image by Dr. Wutian Wu Affiliatio: CTO, Re-Stem Biotechnology, Suzhou, China -nikonsmallworld

[ajibolaaderemi]

sweet !! That is really cool love the breakdown of the hippocampus index, 🔥🔥🔥🔥,

Love it coincidence receptor, haha!!

So what's is the most effective way to strengthen the hippocampal neurons for a specific episodic memories?
Apart from repetition which is 💤💤 ?

[vannevers]

Neat. I am having my hippocampus laser ablated next week and I am so scared about what my memory will function like/or not function like after surgery. I am making videos to share the process if anyone is interested personally...

[resumengon]

keep creating videos, you explain very well

[pocahontas]

This was amazing! Thank you so much ❤✨🙏

[downhillphilm.]

my wife was diagnosed with Alzheimer's in 2010 at age 59 and is still living in nursing home, mute, completely unaware of her surroundings and immobile bed-bound.... but she can swallow and manage her airway, has to be spoon fed by caregivers and but maintains basic homeostasis. in 2010 her csf showed the expected elevated tau and low amyloid, her MR was diagnostic for "marked hypoperfusion in the frontoparietal and posterior cingulate gyri".

they call it the long good-bye, yes very very long in an otherwise totally healthy non-smoker as she was.

[wkywell]

Well, when you are an engineer and this is your hobby, it's getting kinda complicated because my base is almost non-existent

[antoniovidovic]

simple yet finely structured narration, beautiful voice (!), and simple easy to follow animations and schemes. thank you so much for this and ur last video(LTP) :DD

[financetips]

Thank you. This is great. Is there a video thst can show how to activate and stimulate this part of the brain.

And show how the memory differs in the Hippocampus compared the Basal Ganglia.

Thank you! May your channel grow with such great content

[mirriamchundula]

Super insightful! Took me back to when I studied psychology. The brain is a powerful thing! 🔥 when’s the next episode?

[mrthg]

Thank you ! You have a lovely voice :D

[dheyaaalsallami]

Your wonderful work is highly appreciated, Thanks

[Caledonian]

Wonderful work Chanel as always!! Reading looking forward to seeing more of your videos!

[hippocampus]

Me encanta. ¡Espero su siguiente vídeo sobre potenciación a largo plazo! Saludos desde Perú

[MM-byke]

Great video, great narrative. Lovely voice

[psychedelictacos]

4:11 Nice hippocampal beatbox at the end!

[andradatomoni]

Concise and easy to follow! Awesome stuff :)

[yohannchineegadoo]

Brilliant, thank youu!
Love your voice btw

[arbenhajri]

Very usefull video about hpcmps. Insightfull and attractive

[Pinkmedical]

Great to time through this video I came to known about the full form of CA neuronal cell also tried to make one tutorial session on memery & neuroplasticity....in my channel... 🙏

[IDMYM]

I liked your explanation.

I want to suggest that you should introduce/describe whatever thing being talked about as its first appearance. Like CA1234 thing could have been described earlier.