Recrystallization of Amines: A Step-by-Step Purification Guide

Recrystallization of Amines: A Step-by-Step Purification Guide

🧪 Today we will take an in-depth look at the process of recrystallization of amines, an important method for purifying organic compounds in chemistry.

Recrystallization is a purification method that allows for the isolation of a pure substance from a mixture based on differences in solubility. In this case, we will work with amines and demonstrate how to effectively apply this method to obtain high-purity samples.

👩‍🔬 This video will be useful for chemistry students, researchers, and anyone interested in methods for purifying organic compounds.

[michaeljacques]

This is just about the worst way to go about this. Yields will be terrible and it will take forever. Most HCL salts of amines are very soluble in water, usually around 1g per ML. so if you have even a tiny bit of liquid to pour off you are loosing grams of product. Also amines in water like to form an oily liquid tat can take a week to dry even in very low humidity. if you allow this liquid to dry completely globs of crystals bind together trapping impurities that wont come out in the washing step.

The best way to purify amines without vacuum distilling them is to re crystallize from boiling alcohol. put your product in a beaker with just enough dry alcohol to make it completely wet, heat until the alcohol begins to boil. Add more alcohol a few drops at a time until all of your amine dissolves . remove from heat and let your mixture cool as slowly as possible. finish by putting it in the freezer over night. in the mourning you will have large crystals in your solution. filter off the crystals and wash with ice cold acetone. you can get to 99% purity tis way with less then a 5% loss if you do it well.

[anthenriqe]

Took almost 2 months crystallize from evaporated ethanol. Thats crazy

[jaimeortega]

Yes, it looked like you got a better purification out of the recrystallization process than from the acetone filter rinse? Usually, acetone rinses get those quite white and clean. However, even after slow recrystallization I still detected some orange/yellow impurity still present in the crystal? What is that?

[johannweidinger]

Can the amine hydrochloride also be used as a powder and dissolved in water?