Autophagy Mechanism | Mitophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or dysfunctional components.[3] It allows the orderly degradation and recycling of cellular components.

Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. Mitophagy promotes turnover of mitochondria and prevents accumulation of dysfunctional mitochondria which can lead to cellular degeneration. It is mediated by Atg32 and NIX and its regulator BNIP3 in mammals. Mitophagy is regulated by PINK1 and parkin proteins. The occurrence of mitophagy is not limited to the damaged mitochondria but also involves undamaged ones.

Autophagy has roles in various cellular functions. One particular example is in yeasts, where the nutrient starvation induces a high level of autophagy. This allows unneeded proteins to be degraded and the amino acids recycled for the synthesis of proteins that are essential for survival.

[kirstincook]

I'm currently studying for pathology boards and your videos have been incredibly helpful. Thanks!

[aparna]

Best video I have watched on this topic, and the only video and explanation that has actually made me understand this topic. I profusely thank you !

[havzaimtiaz]

Your videos based on current research ....and it saves a lot of time to go through the reference books

[Cali_Girl]

. Can Cancer utilize Autophagy as its own surival mechanism ?

[CarefreeRambler]

I have no idea why I'm watching this, but sounds interesting. Keep up the good work!

[bhushansong]

Thanks for the detailed explanation on this topic. Very rare. Great work sir

[bobcocampo]

Please discuss autophagy and retinopathy

[AliBaba-hntv]

Your way of teaching is genius, thank you sir.

[ranjanghosh]

I went through some videos made by you.. attractive videos sir.. nice

[mariaclaraprates]

this video helped me
impressed how creative God is
Jesus loves you

[Wordboost]

Please make video lectures on types of autophagy... Like macro, micro, chaperone mediated Autophagy... 🙃

[jerrytom]

Not sure if I learned anything —- But nice job

[berdeski]

.75x playback speed slows the audio making the audio more clear...

[darshikasrivastava]

Kind of a quick revision... is this the complete pathway including all biomolecules needed for autophagy???

[robertsmyk]

Please explain how autophagy occurs in human cells when nutrition is supplied from the liver even while the person is fasting or starving.

[RabiaHumayunKhan]

thnx a lot .cancer kay baray main bata dain in detail (cancer pathology and pathways), leukemia cancer and husky subtypes with pathways and lungcancer +subtypes and pathways. and yeh wala pathway where did you study from?

[manjukkrishnan]

Sir can u make a video on gene for gene concept

[shankysays]

I was reading about water fasting and how it activates autophagy.

[boyabdullah]

Assalamualaikum brother. Thank you for this. Could you please make a video about AGEs (Advance glycation end products)? I love your channel and all its content! Much love, from Brunei

[hosnearabegum]

Muslims all over the world do fasting for a mounth in every year. They do fasting from before sun rise to sun set. From 1400 years ago Islam started the fasting.