DNA replication 🧬 #cellbiology #dna #life #science

Explore the steps of DNA replication and the enzymes involved.

A quick summary of the DNA replication process.
1) The enzyme DNA helicase unwinds the double-stranded helix and splits it into leading and lagging strands.
2) Separated strands are held in position by single strand binding proteins.
3) The enzyme Primase adds RNA primers to both strands.
4) DNA polymerase adds complementary nucleotides to RNA primer on leading strand from 5' to 3' direction continuously.
5) DNA polymerase adds short DNA sequences known as Okazaki fragments on the lagging strand from 5' to 3' direction discontinuously.
6) Primers are removed by enzyme Exonuclease.
7) DNA polymerase replaces removed RNA primers with DNA nucleotides.
8)Enzyme ligase seals the bonding between nucleotides and also stabilizes pairing of template strands with new daughter strands.

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Audio credits: @Positive Energy (Kordhel)