The GABA receptor | How does it work?

A short video on how benzodiazepines, barbiturates, BZ agonists like zolpidem, and how antagonists like flumazenil work. The focus is on the GABA receptor and an explanation of CNS depression. View the rest of my posted videos below:

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DRUG ABSORPTION Videos:
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DRUG DISTRIBUTION Videos:
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DRUG METABOLISM Videos:
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DRUG ELIMINATION / EXCRETION
(12) Drug Clearance: [not yet posted]
(13) Practice problems: [not yet posted]
(13) Dosage Regimens: [not yet posted]
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Factors That Affect Drug Metabolism:
(17) Acetaminophen toxicity (Clinical Correlate): [Not yet posted]
(19) Slow Acetylators - Pharmacogenomics: [not yet posted]

Help us caption & translate this video!

[maxinemurphy]

you just explanined to me in ten minutes what my teacher could not make me understand in two months - thanks a lot!

[vishalbarnela]

Thank you very much Areo. I searched for this topic to get clear on the mechanism of action of Zolpidem to prepare my board exam to become a pharmacist. Your video is very effective because the diagrams gave me multiple viewpoints of the receptor--from a close up of a receptor, to how it fits in neuronal action. It's comprehensive and organized, and that's why I'll be able to pay it forward by telling my future patients about their Zolpidem! Thanks again and please continue doing what you're doing.

[ken]

hello im a nursing student and this short 9 minute video helped me understand and connect the dots for CNS depressants, receptor binding, GABA, and differences between drugs, so thank you :)

[camilobjrktr]

In spanish there aren't many videos about pharmacology as well explained as this one. Despite the language, i understood everything and clarified my doubts. Thanks!!!

[joem]

Excellent presentation! I wish you had been my instructor in Pharm school! Thanks!

[Canada]

Man its crazy how good these colors look!

[Wandelaarke]

You sir, have a nice project here. You manage to explain everything perfectly, the slides are good, the pictures are explained and your voice doesn't sound like every other person on youtube explaining interesting stuff (yes we all know what it mostly sounds like...

I normally don't subscribe to people but you really earned it!

[TheAncientScholar]

I just wanted to comment on the GABA(B) receptor discussion.  GABA(B) receptors are g-protein coupled; however, they are able to open Potassium channels. A special type of Potassium channel known as a g-protein activated inwardly rectifying K+ (Potassium) Channel or GIRK channel will open in response to GABA(B) receptor "activation." Great, informative video. Thank you for posting.

[FramedProductions]

Great video! I just had to start taking Lorazepam and its nice to find such a clear description of whats going on.

[desoan]

really helpful video! just a note that the GABA B receptor isn't a potassium channel, it's a GPCR that activates other potassium channels

[sahel]

That was so great and informative, I have an exam two days later and I finally understand sedative-hypnotic drugs
thank you

[wafikiri_]

The post-synaptic potential is not an action potential but a graded potential. Apart from that, a good explanation.

[jennyeckhardt]

I recently began taking Baclofen. Life-changing. I would love to see an explanation of how it works. Please consider a more detailed lecture. Your presentations are helpful.

[Assistboy]

Thank you for making this stuff fun to learn and review. You certainly have a gift for making complicated stuff understandable. Great Job!

[hammad]

it is really nice to watch your videos, they make pharmacology so much easier to understand. please make more videos if you can and especially on cns. thank you

[sofiaeri]

just "ouaouuu" now I love GABA receptors.Thank you so much, you are an excellent teacher!

[cenatrunkss]

He has just diluted this topic well done

[sbcand]

Amaying colors, dude... and completely beside the point, also a great intro to GABA, thanks ;)

[jimbob]

You forgot the best part. After you use Benzos or "Z" drugs for more than two weeks, the GABA receptors down regulate. Then you need to take more of your Benzo or "Z" drug to have the same effect. The longer you use them, the more they down regulate your GABA receptors.

And if you decide you want to stop taking them? It can take months or years for your GABA receptors to up regulate back to normal. Meanwhile, you will be in a special kind of hell while you wait for your GABA recptors to up regulate back to normal.

Benzos are extremely effective, but be very careful. Once you are on them, they can be extremely difficult to get off of for a significant percentage of the population.

[RylonThomas]

Love this presentation style, thank you for helping me study for my exam!