Type 2 Diabetes: Pathophysiology

Pathophysiology of type 2 diabetes mellitus
Diabetes
Risk factors
Insulin resistance

[FightBackAgainstDiabetes]

*You Did Not Choose To Be Classified As Diabetic, But You Can Choose To Fight Back Against Diabetes* 💪

[KrazyKordi]

Very nice and to the point. Makes understanding it easier for the visual people out there! Thank you

[garrygalvez]

Can you explain the contribution of each risk factors?

1. Obesity - why have one become obese in the first place - means more fat stored instead of used? So eat less glucose? Calorie restriction recommended so that no fat build up in the adipose tissues? If one continually eats carb/glucose, glucose level at the cell, blood stream and muscles are always high, how will the fats be removed from storage (thereby losing the fat/losing weight) and be used as fuel by the cells?

2. Sedentary - why simply not moving causes insulin resistance of cells? Is it just a compounding factor with obesity? Or exercise not enough? There are far people that apparently exercises normally, but are not losing the weight. Are they still at risk, with risk factor #1 above?
3. Hereditary - can you specify what gene contributes to deactivation of insulin receptors at the cell level? Have they been mapped? Is the gene responsible for receptor deactivation or are the genes contributory to appetite suppression or activation, which leads to risk factor #1. Again this has something to do with why one eat and not gene expression of sensitivity deactivation?

Not once in you talk did you mention about excess food and quality of food intake.

Is there a preference of order on how glucose is used in the body —> (1) glucose are transported first to the cell for fuel, then (2) stored as glycogen in the liver and muscle, then the excess are (3) stored as fat in the tissues? This order would matter highly since if people would eat the caloric equivalent of their physical activity, then fat would not be stored and obesity will not happen (which you mentioned as the first of the risk factors in T2D).

Why is there a lock and key mechanism (Insulin and receptors) within the cells just to consume glucose as a fuel for the cells? You mean it is not a natural source of fuel for humans along the evolutionary timeline? Do fats (triglycerides/fatty acids) have the same lock and key mechanism in the cells to enter and be used as another source of energy in the cell? If none, so it means fats are the energy of of choice of cells, and not glucose?

So many questions for you, sir.

[ayisha]

such a great breakdown, easy to understand and puts it into context very well. Thank you!

[boscolau]

Thank you! Very clear explanation! you won't know how much I appreciate you.

[MoahGentle]

Every day I feel thankful that I don’t have diabetes.. thanks for the relatively simple explanation!

[annachang]

Awesome video! very helpful. Thanks Dr. Matt!!

[anitaalexandria]

Can you increase the volume a bit more? hard to hear what you're saying!

[nanaperry]

Well explained and understood. Thank you!

[vzmrszw]

You guys are the best❤❤
I watched ur video on pathophysiology of hypertension and was so happy
Kudos🙌🙌

[kwikirizamable]

Thanks you so much explaination was clear

[long]

thank you so much, this was an amazing explanation

[hedon]

Can you explain the somogyi effect and also the relationships between counterregulatory hormones and glucose?

[cheriehanson]

You have not spoken about cutting out carbs and glucose so that hyperinsulemia does not occur

[ozb]

i would love to listen if you fix the audio it's so low..

[ericli]

Most good, but he said pancreas doesn’t release insulin anymore is not correct

[adamualiyukukawa]

Words failed me on how to appreciate you for sending your Herbs to me after I place my or order which cured my diabetes Dr Igudia.

[yvonnereed]

Poor quality diet (including toxic substances that get into food as well as high sugar/fat/salt and low micronutrients etc) underlies most of the risk factors. Doctors and scientists need to focus much more on environmental factors (genetic changes in an entire population take many generations. A sudden increase in incidence of a disease within one to two generations is environmental) instead being lead by the pharmaceutical and food industry through finding incentive/disincentives in a poorly set up societal governing system for health care.

Mitochondrial disfunction from ingesting toxins (anything from pesticides and household cleaners to food preservatives) leads to protein malformations including enzymes, receptors, amyloid plaques etc) the newest evidence is that chronic disease and cancer are metabolic but mainstream science takes too long to catch up.

[olayemiolawoyin]

I don’t know what I would have done without your help. Thank you so much for curing my type 2 Diabetes with your herbs Dr Igudia

[sagaljobbenbosco]

This is great, i really appreciate your explanations easened my understanding