Label-free live cell imaging of macropinocytosis (cell drinking)

Pinocytosis is a non-specific cell drinking. Pinocytosis is the process where fluid matter coming from the outside of the cell is obtained via invaginations of the cell membrane. Its biological meaning is mainly to absorb extracellular fluids (ECF) containing solutes like sugars or proteins, once triggered by the presence of certain substances outside the cell (amino acids or certain ions) but it is also involved in cell immunity.
As observed in the video, the membrane extends forming arm-like claws that reconnect resulting in a macropinosome (Figure 1). Once at the cytoplasm, the macropinosome fuses with a lysosome.

Technology:
3D Cell Explorer microscope from Nanolive, Switzerland.
The 3D Cell Explorer is a high speed, high resolution and non-invasive live cell imaging microscope that can look deep inside biological systems. This allows you to record stunning 3D images of entire cells in just seconds and with a higher resolution than any conventional microscope on the market.