Penicillin Pharmacology: Mechanism of Action, Spectrum, Therapeutic Uses and Adverse Effects

Penicillin is antibiotic from the cell wall inhibitors and in this video I will talk about the pharmacokinetics, mechanism of action, antibacterial spectrum, resistance, therapeutic uses, adverse effects and drug interactions …

Penicillin molecular weight around 300-500, and it is non ionized but gets ionized when enters the body because of PH, and that make it unable to cross the blood brain barrier but it crosses the BBB during inflammation of the meninges (meningitis) because of leaking of the penicillin through the inflamed meninges…

Penicillin works on the transpeptidase enzyme of the bacteria, it leads to inhibiting the formation of the links between the glycan units of the bacterial cell wall and lead to the bacteria death by the osmotic pressure…

Penicillin used to treat bacterial infections of all types, and it is also used for prophylaxis, specifically the benzathine penicillin is the only antibiotic used for prophylaxis because of long half life of 3-4 weeks, it is used for prophylaxis against rheumatic fever and endocarditis…

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Video Timestamps
0:00 Introduction
1:31 Pharmacokinetics
5:48 Mechanism of Action 1
8:40 Penicillin antibacterial spectrum
12:02 Resistance
14:13 Therapeutic Uses
16:31 Adverse Effects
20:07 Drug Interactions