Psychedelic Science in 2020 | An overview of the psychedelic renaissance

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We are in the midst of a huge resurgence of scientific interest in psychedelic substances. They are now being shown to have great potential for a variety of applications - from treating mental conditions, to enhancing our meditation practice, to increasing our connection to nature.

In this video, I give a broad overview of the latest exciting psychedelic research being conducted at leading institutions across the globe!

Don't forget to follow me on social media for all the latest updates:

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More info about the host:

Manesh Girn is a Neuroscience PhD student at McGill University and has been lead or co-author on over a dozen scientific publications and book chapters on topics including psychedelics, meditation, daydreaming, and brain networks.

Manesh currently has ongoing collaborations with Robin Carhart-Harris and others at the Imperial College Center for Psychedelic Research and is investigating the brain changes underlying psilocybin, LSD, and DMT.

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On popular request, here are the papers I refer to in this video (in no particular order):

1. Carhart-Harris, R.L., et al., Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. The Lancet Psychiatry, 2016. 3(7): p. 619-627.
2. Lyons, T. and R.L. Carhart-Harris, Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression. Journal of Psychopharmacology, 2018. 32(7): p. 811-819.
3. Johnson, M.W., et al., Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. Pharmacology & therapeutics, 2019. 197: p. 83-102.
4. Griffiths, R.R., et al., Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. Journal of psychopharmacology, 2016. 30(12): p. 1181-1197.
5. Johnson, M.W., et al., Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction. Journal of Psychopharmacology, 2014. 28(11): p. 983-992.
6. MacLean, K.A., M.W. Johnson, and R.R. Griffiths, Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness. Journal of Psychopharmacology, 2011. 25(11): p. 1453-1461.
7. Griffiths, R.R., et al., Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later. Journal of Psychopharmacology, 2008. 22(6): p. 621-632.
8. Griffiths, R.R., et al., Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology, 2006. 187(3): p. 268-283.
9. Carhart-Harris, R.L. and K.J. Friston, REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics. Pharmacological Reviews, 2019. 71(3): p. 316-344.
10. Carhart-Harris, R.L., et al., Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences, 2016. 113(17): p. 4853-4858.
11. Carhart-Harris, R.L., et al., Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proceedings of the National Academy of Sciences, 2012. 109(6): p. 2138-2143.
12. Krebs, T.S. and P.-Ø. Johansen, Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials. Journal of Psychopharmacology, 2012. 26(7): p. 994-1002.
13. Girn, M., et al., Updating the dynamic framework of thought: Creativity and psychedelics. NeuroImage, 2020: p. 116726.
14. Baggott, M.J., Psychedelics and creativity: a review of the quantitative literature. PeerJ PrePrints, 2015. 3: p. e1202v1.
15. Ross, S., et al., Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial. Journal of psychopharmacology, 2016. 30(12): p. 1165-1180.
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Your moving between philosophy, brain mechanics, and subjectivity inspires me to keep wondering. Yes! Psychedelics' forging novel neural conceptions ignites creativity. Also, commitment, discipline organizational capacity contribute to the artist's process. Developing self discipline - to dance, paint or act - can be aided by the self knowledge and the diversities of subjective experience psychedelics offers. Thanks.

MsLindance
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Some timestamps for you all to help navigate the video!

Treatment of Mental Health Disorders 0:58
Neuroscience Research 4:47
Ego-Dissolution 6:36
Mystical Experience 7:29
Positive Psychedelic Effects in Healthy Individuals 8:17

ThePsychedelicScientist
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Thanks for such a in-depth look at psychedelic studies. The dual aspect of psychedelics, helping healing mental health issues and possibility of enhancing wellness, is an exciting prospect. With the groundswell of support building, it feels like we may be able to hope that these plant and synthetic medicines could impact the world in such a positive way. Looking forward to more of your content, thanks for sharing.

counsellingwarwickshire
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My man, this channel is about to blow up. I literally watched every single one the other day, haha. I'd love to see some podcasts with some of your colleagues or other researchers in the future!

EvanNagao
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Thanks for making these developments accessible to the everyday non science person! We really appreciate it!

racavelino
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This is an incredibly valuable service you're providing here Manesh. Thank you. Also, you're very natural in your presentation, which makes the info easy to digest.

geoffmackenzie
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This is all so interesting. Thanks for listing the topics on the screen - found that extremely useful. Excited for your future content!

srijeetm
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Really clear explanations. No wasted time.

PsytranceGOUGAS
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Wow, awesome video and channel - you summed it all up very succinctly which is super helpful as I get a bit lost with all the novel research sometimes! I can’t wait to see your future videos :)

estelleghost
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Hello Manesh, I am grateful towards you for bringing us a recent overview. I might get inspired from your videos for my pharmacist thesis, spreading this knowledge in a simple way.
Now we have to speak about the Integration part and bring ideas to create anywhere is needed spaces for this specific and fundamental step, bringing together individual healings into the collective.
Looking forward for new quality content!

ektanne
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If we could show compassion to the dying by giving them Psilocybin then why wouldn’t we?
Psychedelic plants and fungi are a gift. They are our teachers and can help us cope with the human condition. 🙏🏼

SuperStargazer
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Wow! So much current research being done on psychedelics these days! Do you also have a website/blog where you summarize these videos and provide links to all the articles you cited? It would be awesome if there were a central online platform with all of these resources.

leeastott
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Great video! It's so interesting to see all the different kinds of studies that have been done! I look forward to your future videos!

joylynsecunda
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Thank you so much! 40 years and trying almost all antidepressants and I still pray for death. Prozac caused me such a horrible experience it has caused problems decades later. Suicide attempt with gun although gun jammed I still had more attempts. Where in Phoenix can I find help?
Thank you

trinity