Live webinar with Dr. Theoharis Theoharides

Dr. Theoharis Theoharides has been studying the regulation of mast cells and their role in allergic and inflammatory diseases for over 30 years. He was the first to report that mast cells can,

(a) Secrete specific mediators selectively without degranulation
(b) Regulate blood-brain-barrier permeability
(c) Be activated by corticotropin-releasing hormone (CRH) secreted under stress to release VEGF selectively
(d) Be activated by synergistic action of CRH and neurotensin
(e) Be activated by IL-33 and substance P (SP) synergistically to secrete the pro-inflammatory cytokines IL1-beta and TNF;
(f) Secrete mitochondrial DNA (mtDNA) extracellularly that is mistaken by the body as a pathogen resulting in inflammatory reactions
(g) Communicate with microglia and are involved in inflammation of the brain especially as they may relate to n the pathogenesis of Autism Spectrum Disorders, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Mastocytosis, diseases that are often comorbid and affect multiple organs without effective treatment

Dr. Theoharides has shown that secretion of mast cell mediators is inhibited by the natural flavonoids luteolin and methoxyluteolin. His laboratory has been committed to uncovering ways to regulate secretion of mast cell mediators for which there is no clinically effective drug since the only “mast cell blocker” cromolyn in weakly effective and shows rapid tachyphylaxis.

He has published over 449 peer-reviewed papers and has been placed in the top 5% of authors most cited in pharmacological and immunological journals.

In this live chat, we will discuss the role of mast cell activation in the pathogenesis of Autism Spectrum Disorders.

#AutismIsMedical #AutismIsTreatable #1in54 #FlattenTheAutismCurve