TWiV 657: Shane Crotty on SARS-CoV-2 immunity

Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions.

[johnbelcher]

Intelligent conversations among intelligent people about an interesting topic is always my favorite form of entertainment. To be sure, I am grateful for your service to the world concerning our understanding of science and disease. I also want to express my gratitude for hours and hours of some of the best entertainment to be found.

[-homerow-]

It's so great to have lifelong experts to ask the questions I want answers to (to other experts). I love the main TWiV crew. You all teach me so much about listening, podcasting (same difference, right?), and of course virology, the current information, endless specifics, the context of society, and How to use a Patient approach to Convey Information that you Care Passionately about. This podcast (among others) is a guiding light through the endless dark times of uncertainty in all the caverns that connect the human experience of observing life and the world on Earth.

[SophyaAgain]

2:00 Rich, that reminds me of a girl - way younger than me - who told me she had dificulty in reading analog clocks. When she was born it was already digital world.

[stevengr]

Thank you for posting. I download the Twiv podcast to Itunes for times I'm away from the internet.

[lilkatielady]

This was a triumph. I'm making a note here. Huge success.

[alexserrell]

I love listening to these before bed. Especially after s successful day studying Biochem 1

[nxjitki]

Fascinating last section on cross immunity from common cold corona viruses but lots more still to learn... I, ve been a total TWiV fan on all things Covid-19. My go-to channel. Thank you.

[jeanmckenney]

love the ability to explain... been a long time since immunology class

[honurider]

I really like how Shane, communicates

[Thebigotry]

Dammit Vincent I'm trying to sleep! How am I supposed to sleep with all this racan-yelling going on?

/sarcasm

[yru]

1. Wow, just wow. This hits so many of the topics that have been TWIViated in recent weeks.
2. In my line of work, I am closely exposed to dozens of teenaged children on a daily basis. It has not been surprising to me that in most years I have a cold or indications-of-infection on a recurring basis. In some years it seems nearly constant. What does this say about the immunology of the respiratory viruses we are routinely exposed to, and what might it say about my poor immune system?

[cab]

Would you posit that those of us referred to as “long haulers” might have a higher B cell and memory T cell immunity protection? Would we be thought of as having had a higher viral load, thus a lingering systematic disease? After there is a vaccine, will the health care systems follow up with a titter test to see if we have developed an immune response? What if we don’t show a titter response to the vaccine? Lots of unknowns. I am a “long hauler” who had 2 negative antigen drive through tests, not the CDC PCR test. I did go to a COVID-19 clinic for lung x-rays, labs and physical, determined to be SARS-CoV-2 positive from clinical assessment. No antibody test has been done by my health care system. I’ve been ill since March 22, 2020. And, I add my self reported data to the ZOE study daily.

[WooliteMammoth]

No comment on the HK paper (yet unpublished) that "confirmed" reinfection or the European doctors that documented the same?

[judyweber]

Most studies I have seen cited regarding infectious rate (transmission) in children generally compare adults infecting adults and children infecting adults. How about children infecting children. They are inhaling and exhaling in the same area of the air column. Is it harder for adults to inhale a child’s exhale when they are 1.5 to 2 feet higher up in the air column. I would think children exchanging air at the same level in the air column might transmit disease to each other better than to adults. They might not show disease, but this does not mean they are virus free. Given that children/parents are often at the same level transmission to this specific group might be higher than just children to random adults.

[drewetpa]

I would have preferred for Shane to be on for 2 hours which is likely difficult because he must be a busy man. Alternatively I'm less interested in his history and more in his knowledge of SARS-COV-2 and his research and it's a pity there wasn't longer to dig deeper.

[Ky_L]

Hello! I totally love TWiV!! I have a question, in this or another episode, I remember one of your guests talking about how long a person can spread the virus after they've been infected. If I remember correctly, they said: someone can spread the virus (on average) 2 days before they show symptoms and for 5 days after they've shown symptoms - so a total of seven days, right? But in my country we have to do quarantine for 14 days (for example when returning from foreign trips) so why twice that time, am I missing something important (probably I am)? Thanks.

[rosalindmartin]

Wonderful. Thank you.
Hmmm... The thalydomide (sp?) problem came up. Interesting poke into the past. I remember FDR and the polio past. We do learn ...slowly🤗

[tikaanipippin]

I believe the PPD skin test for Tuberculin tests (Heaf, Mantoux etc.) indicates the T-cell ability to maintain a response to TB infection long after the initial infection/immunisation. Why should this not be the same for SARS-CoV-2?

[anothercanucknoob]

Vincent with the PORTAL video game tshirt ... amazing :D

[jdcjr]

"an island of sanity...." - Rich Condit At least the high-test (expensive) Abbott test was finally approved