Nuclear Disruption in Pre-Adipocytes by CDK2 Inhibition

Nuclear Disruption in Pre-Adipocytes by CDK2 Inhibition
In this video, we observe how 3T3-derived pre-adipocyte cells respond to a CDK2 inhibitor. CDK2 (Cyclin-Dependent Kinase 2) inhibitors are compounds that block the activity of Cdk2, a key regulator of the cell cycle.

Nanolive's live cell imaging platforms monitor key features of severe nuclear disruption caused by CDK2 inhibition, including structurally disorganised nucleolus and thickening of the nuclear membrane, label-free. Our technology accelerates drug discovery, development and compound testing.