Pathology of Alopecia Areata: Pathomechanisms, theories, immunopathologies

#skin #hair #haircycle #alopecia #hairloss #hairfall #skindiseases #skincondition #skincare #haircare #hairanatomy #hairpathology #biopsy

Introduction - 01:30
Pathogenesis: Factors and Hypotheses - 05:20
A. Auto-immune Hypothesis - 08:55
B. Immune Privilege Breakdown - 17:54
Pathogenesis - 21:50
C. Genetics - 26:18
D. Environment Factors - 27:35
E. Associated Diseases - 28:33
G. Hair Cycle Alterations - 29:16
Auto-immune Alopecia Areata - 31:44
Future Insights - 33:35
Further Reading - 35:25
Ruby Membership to the Channel - 35:40
Sapphire Membership to the Channel - 36:08
End - 37:37

Further Reading:

1. Chapter 87 – Acquired Disorders of Hair. In: Rooks Textbook of Dermatology, 10ed. Pg-87.1, Harries MJ et al.

2. Chapter 87 – Alopecia Areata. In: Fitzpatrick’s Dermatology, 9ed. Pg-1517, Otberg N et al.

3. Chapter 69 – Alopecias. In: Bolognia’s Dermatology, 5ed. Pg-1173, Rudnicka L T et al.

4. Lu W, Shapiro J, Yu M, Barekatain A, Lo B, Finner A, McElwee K. Alopecia areata: pathogenesis and potential for therapy. Expert Rev Mol Med. 2006 Jun 20;8(14):1-19.

5. Yamaguchi HL, Yamaguchi Y, Peeva E. Pathogenesis of Alopecia Areata and Vitiligo: Commonalities and Differences. Int J Mol Sci. 2024 Apr 17;25(8):4409.

6. Spano F, Donovan JC. Alopecia areata: Part 1: pathogenesis, diagnosis, and prognosis. Can Fam Physician. 2015 Sep;61(9):751-5.

7. Rajabi F, Drake LA, Senna MM, Rezaei N. Alopecia areata: a review of disease pathogenesis. Br J Dermatol. 2018 Nov;179(5):1033-1048.

8. Dainichi T, Kabashima K. Alopecia areata: What's new in epidemiology, pathogenesis, diagnosis, and therapeutic options? J Dermatol Sci. 2017 Apr;86(1):3-12.

9. Trüeb RM, Dias MFRG. Alopecia Areata: a Comprehensive Review of Pathogenesis and Management. Clin Rev Allergy Immunol. 2018 Feb;54(1):68-87.

10. Paus R. The Evolving Pathogenesis of Alopecia Areata: Major Open Questions. J Investig Dermatol Symp Proc. 2020 Nov;20(1):S6-S10.