Brian Miller on the Limits of Protein Evolution

[roy]

Very interesting. Good mental images of how these tiny islands of functional proteins are floating in an absolutely vast universe of protein space.

[ikemiracle]

I love how cleanly you explained the issue, spectacular. But Could you please make this in a video format for a much clearer understanding. The mechanics of proteins is actually an area I want to fully understand, making a 3d video of this would really be helpful.

[edcroteau]

Brian is the best.... really enjoy learning from him.

[LarghettoCantabile]

It could be a good thing to have references written under the video. Even though Dr Axe's paper is very rigorous, including in the extrapolation leading to 10 to the negative 77 (obviously not a statistical count!); but inevitably one would like to know what other researchers have found on the question. youtube's voice recognition points us to " Yaky or sour", and I had some difficulty identifying this researcher as Yoichi Osawa ...

The Martin Nowak reference seems to be to "The Time Scale of Evolutionary Innovation".

P. Tian, R.B. Best
How many protein sequences fold to a given structure? A coevolutionary analysis
Biophys J, 113 (2017), pp. 1719-1730

[chrisxavier]

Evolution doesn't have what it takes to design - a MIND.

[davidjewell]

You'd have a better chance getting away from a pride of lions while wearing a pair of pork chop pannys

[brandonmacey]

You’d have a better chance playing pick up stix with your butt cheeks