From Structure to Function: Combining the Power of Cryo Electron Microscopy and Mass Spectrometry...

Presented By:
Edward Pryor, PhD - Director, Product Management, Thermo Fisher Scientific
Pascal Albanese, PhD - Utrecht University
Albert Konijnenberg, PhD -Product Manager, Cryo-EM Sample Preparation and Integrative Structural Biology, Thermo Fisher Scientific
Rosa Viner, PhD - Senior Marketing Manager, Omics, Thermo Fisher Scientific

Webinar:
From Structure to Function: Combining the Power of Cryo Electron Microscopy and Mass Spectrometry for Deeper Insights

Webinar Abstract:
Scientist must look beyond studying individual proteins and examine the structure and assembly of protein complexes within cells in order to truly understand how proteins function in their native environment. The emergence of cryo-electron microscopy (cryo-EM) has resulted in the ability to directly visualize complete macromolecular complexes in near-atomic level resolution. Combined with advances in mass spectrometry (MS), these methods have had a considerable impact on structural biology research, enabling researchers to characterize biomolecular structures with greater speed, sensitivity and selectivity. Dr. Pascal Albanese discuss the characterization of a key enzyme of the central carbon metabolism of Pyrococcus furious, through an integrative approach combining structural mass spectrometry, cryo-electron microscopy, mass photometry and molecular modelling with molecular dynamics simulations. He will describe how his lab unveiled the structural organization of phosphoenolpyruvate synthase (PPSA).

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