USMLE Step 1 - Lesson 32 - Genetic terms Part II

This video covers Dominant-negative mutations, linkage disequilibrium, mosaicism, locus heterogeneity, allelic heterogeneity, heteroplasmy, and uniparental disomy.

Dominant-negative mutations:
- heterozygotic makes a protein that stops the function of normal protein

Linkage disequilibrium:
- variation of 2 linked genes to occur together

Mosaicism:
- two cell lines in the same organism
- somatic - mitotic errors after fertilization
- gonadal - mutation in egg or sperm

Locus heterogeneity:
- mutations at different loci result in a similar phenotype

Allelic heterogeneity:
- One phenotype from different mutations in the same locus

Heteroplasmy:
- normal and mutated mitochondrial DNA (mtDNA)

Uniparental disomy:
- 2 copies of chromosomes from 1 parent, none from the other

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[gpain]

Lol bring back the guy with the deep voice.

[kaABC]

The problem is with the person explaining! He may be a journalist reading the news! Please do not read the text! It is not a way of teaching.

[nenosaleh]

genetic videos are not good as the rest videos < BTW thank you :)

[urveshdevani]

Very bad voice and unclear explanation and not good, plz make it again with previous voice